| 13th Nov 2018 9:17 am | 
                                            PRN | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 13th Nov 2018 9:13 am | 
                                            RNS | 
                                            Form 8.3 - SHIRE PLC | 
                                        
                                                                            
                                            | 13th Nov 2018 7:16 am | 
                                            RNS | 
                                            Form 8.3 - Shire Plc | 
                                        
                                                                            
                                            | 13th Nov 2018 7:00 am | 
                                            RNS | 
                                            Form 8.3 -TAKEDA PHARMACEUTICAL COMPANY LTD | 
                                        
                                                                            
                                            | 13th Nov 2018 7:00 am | 
                                            RNS | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 12th Nov 2018 4:07 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 12th Nov 2018 4:04 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 12th Nov 2018 3:20 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 12th Nov 2018 3:20 pm | 
                                            GNW | 
                                            Davidson Kempner Capital Management LP : Form 8.3 - Shire Plc | 
                                        
                                                                            
                                            | 12th Nov 2018 3:15 pm | 
                                            RNS | 
                                            Form 8.3 - Shire Plc | 
                                        
                                                                            
                                            | 12th Nov 2018 2:53 pm | 
                                            EQS | 
                                            Form 8.3 - The Vanguard Group, Inc.: Shire plc | 
                                        
                                                                            
                                            | 12th Nov 2018 2:47 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 12th Nov 2018 2:44 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 12th Nov 2018 2:39 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 12th Nov 2018 2:38 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 12th Nov 2018 2:30 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 12th Nov 2018 2:21 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 12th Nov 2018 2:12 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Replacement of SHIRE | 
                                        
                                                                            
                                            | 12th Nov 2018 2:09 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Replacement of SHIRE | 
                                        
                                                                            
                                            | 12th Nov 2018 2:06 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 12th Nov 2018 1:51 pm | 
                                            RNS | 
                                            Form 8.3 - [Shire Plc] | 
                                        
                                                                            
                                            | 12th Nov 2018 1:50 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 12th Nov 2018 1:21 pm | 
                                            BUS | 
                                            Form 8.3 - SHIRE PLC | 
                                        
                                                                            
                                            | 12th Nov 2018 11:34 am | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 12th Nov 2018 11:22 am | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 12th Nov 2018 10:56 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 12th Nov 2018 10:54 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 12th Nov 2018 10:52 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 12th Nov 2018 10:34 am | 
                                            RNS | 
                                            Form 8.5 - Shire Plc | 
                                        
                                                                            
                                            | 12th Nov 2018 10:32 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) | 
                                        
                                                                            
                                            | 12th Nov 2018 10:30 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Shire plc | 
                                        
                                                                            
                                            | 12th Nov 2018 10:26 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 12th Nov 2018 10:23 am | 
                                            RNS | 
                                            Form 8.3 - SHIRE PLC | 
                                        
                                                                            
                                            | 12th Nov 2018 10:08 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) | 
                                        
                                                                            
                                            | 12th Nov 2018 10:06 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 12th Nov 2018 9:55 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) - Shire Plc | 
                                        
                                                                            
                                            | 12th Nov 2018 9:53 am | 
                                            PRN | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 12th Nov 2018 7:02 am | 
                                            RNS | 
                                            Statement regarding Shareholder Circular | 
                                        
                                                                            
                                            | 12th Nov 2018 7:00 am | 
                                            GNW | 
                                            Rule 2.9 Announcement | 
                                        
                                                                            
                                            | 12th Nov 2018 7:00 am | 
                                            GNW | 
                                            Publication of Scheme Document |