| 9th Nov 2018 7:00 am | 
                                            GNW | 
                                            Rule 2.9 Announcement | 
                                        
                                                                            
                                            | 8th Nov 2018 4:32 pm | 
                                            RNS | 
                                            Statement regarding Issuance of Senior Notes | 
                                        
                                                                            
                                            | 8th Nov 2018 3:34 pm | 
                                            BUS | 
                                            Form 8.3 - SHIRE PLC - AMENDMENT | 
                                        
                                                                            
                                            | 8th Nov 2018 3:32 pm | 
                                            RNS | 
                                            Form 8.3 - Shire Plc | 
                                        
                                                                            
                                            | 8th Nov 2018 3:25 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 8th Nov 2018 3:20 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 8th Nov 2018 3:20 pm | 
                                            BUS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 8th Nov 2018 3:20 pm | 
                                            BUS | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 8th Nov 2018 3:13 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 8th Nov 2018 3:10 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 8th Nov 2018 3:00 pm | 
                                            BUS | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 8th Nov 2018 2:43 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 8th Nov 2018 2:42 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 8th Nov 2018 2:37 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 8th Nov 2018 2:34 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 8th Nov 2018 2:28 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 8th Nov 2018 2:21 pm | 
                                            RNS | 
                                            Form 8.3 - [Shire Plc] | 
                                        
                                                                            
                                            | 8th Nov 2018 2:02 pm | 
                                            EQS | 
                                            Form 8.3 - The Vanguard Group, Inc.: Shire plc | 
                                        
                                                                            
                                            | 8th Nov 2018 1:56 pm | 
                                            BUS | 
                                            FORM 8.3 - SHIRE PLC | 
                                        
                                                                            
                                            | 8th Nov 2018 1:18 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Replacement of SHIRE | 
                                        
                                                                            
                                            | 8th Nov 2018 1:15 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Replacement of SHIRE | 
                                        
                                                                            
                                            | 8th Nov 2018 1:12 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Replacement of SHIRE | 
                                        
                                                                            
                                            | 8th Nov 2018 12:39 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Co Ltd | 
                                        
                                                                            
                                            | 8th Nov 2018 12:36 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 8th Nov 2018 12:31 pm | 
                                            RNS | 
                                            Form 8 (DD) - Takeda Pharmaceutical Company Ltd | 
                                        
                                                                            
                                            | 8th Nov 2018 12:23 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 8th Nov 2018 12:20 pm | 
                                            RNS | 
                                            Form 8.3 - Shire Plc | 
                                        
                                                                            
                                            | 8th Nov 2018 12:15 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 8th Nov 2018 12:03 pm | 
                                            RNS | 
                                            Form 8 (DD) - Citibank NA Zurich | 
                                        
                                                                            
                                            | 8th Nov 2018 11:58 am | 
                                            RNS | 
                                            Form 8 (DD) - Citibank NA Jersey | 
                                        
                                                                            
                                            | 8th Nov 2018 11:46 am | 
                                            RNS | 
                                            Form 8.3 - SHIRE PLC | 
                                        
                                                                            
                                            | 8th Nov 2018 11:30 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 8th Nov 2018 11:06 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 8th Nov 2018 10:58 am | 
                                            RNS | 
                                            Form 8.5 - Shire Plc | 
                                        
                                                                            
                                            | 8th Nov 2018 10:54 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) | 
                                        
                                                                            
                                            | 8th Nov 2018 10:53 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 8th Nov 2018 10:50 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 8th Nov 2018 10:46 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 8th Nov 2018 9:33 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI)- Shire Plc | 
                                        
                                                                            
                                            | 8th Nov 2018 9:20 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) |