| 9th Nov 2018 6:16 pm | 
                                            RNS | 
                                            Form 8.3 - TAKEDA PHARMACEUTICAL COMPANY LTD | 
                                        
                                                                            
                                            | 9th Nov 2018 3:34 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 9th Nov 2018 3:25 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 9th Nov 2018 3:20 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 9th Nov 2018 3:14 pm | 
                                            RNS | 
                                            Form 8.3 - Shire Plc | 
                                        
                                                                            
                                            | 9th Nov 2018 3:02 pm | 
                                            RNS | 
                                            Form 8.3 - [Shire Plc] | 
                                        
                                                                            
                                            | 9th Nov 2018 3:00 pm | 
                                            BUS | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 9th Nov 2018 2:34 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 9th Nov 2018 2:30 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Co Ltd | 
                                        
                                                                            
                                            | 9th Nov 2018 2:29 pm | 
                                            RNS | 
                                            Form 8 (DD) - Citibank NA Switzerland | 
                                        
                                                                            
                                            | 9th Nov 2018 2:26 pm | 
                                            EQS | 
                                            Form 8.3 - The Vanguard Group, Inc.: Shire plc | 
                                        
                                                                            
                                            | 9th Nov 2018 2:26 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Replacement of SHIRE | 
                                        
                                                                            
                                            | 9th Nov 2018 2:24 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Replacement of SHIRE | 
                                        
                                                                            
                                            | 9th Nov 2018 2:24 pm | 
                                            RNS | 
                                            Form 8 (DD) - Citibank NA London | 
                                        
                                                                            
                                            | 9th Nov 2018 2:23 pm | 
                                            RNS | 
                                            Form 8 (DD) - Citibank NA Jersey | 
                                        
                                                                            
                                            | 9th Nov 2018 2:22 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Replacement of SHIRE | 
                                        
                                                                            
                                            | 9th Nov 2018 2:21 pm | 
                                            RNS | 
                                            Form 8 (DD) - Citibank NA Zurich | 
                                        
                                                                            
                                            | 9th Nov 2018 2:12 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 9th Nov 2018 2:00 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 9th Nov 2018 11:56 am | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 9th Nov 2018 11:54 am | 
                                            RNS | 
                                            Form 8.3 - Shire Plc | 
                                        
                                                                            
                                            | 9th Nov 2018 11:52 am | 
                                            BUS | 
                                            Form 8.3 - SHIRE PLC | 
                                        
                                                                            
                                            | 9th Nov 2018 11:51 am | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 9th Nov 2018 11:25 am | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 9th Nov 2018 10:57 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 9th Nov 2018 10:48 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) - Shire Plc | 
                                        
                                                                            
                                            | 9th Nov 2018 10:48 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Shire plc | 
                                        
                                                                            
                                            | 9th Nov 2018 10:43 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 9th Nov 2018 10:41 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 9th Nov 2018 10:40 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 9th Nov 2018 10:33 am | 
                                            RNS | 
                                            Form 8.5 - Shire plc | 
                                        
                                                                            
                                            | 9th Nov 2018 10:17 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) | 
                                        
                                                                            
                                            | 9th Nov 2018 10:15 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 9th Nov 2018 10:10 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) | 
                                        
                                                                            
                                            | 9th Nov 2018 9:57 am | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 9th Nov 2018 9:56 am | 
                                            RNS | 
                                            Form 8.3 - Shire Plc | 
                                        
                                                                            
                                            | 9th Nov 2018 8:32 am | 
                                            PRN | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 9th Nov 2018 8:05 am | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 9th Nov 2018 7:57 am | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 9th Nov 2018 7:00 am | 
                                            RNS | 
                                            Form 8.3 - Shire PLC |