| 8th Nov 2018 9:19 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI)- Shire plc | 
                                        
                                                                            
                                            | 8th Nov 2018 8:52 am | 
                                            PRN | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 7th Nov 2018 3:54 pm | 
                                            RNS | 
                                            Form 8.3 - TAKEDA PHARMACEUTICAL COMPANY LTD | 
                                        
                                                                            
                                            | 7th Nov 2018 3:28 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 7th Nov 2018 3:27 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 7th Nov 2018 3:20 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 7th Nov 2018 3:12 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 7th Nov 2018 3:08 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 7th Nov 2018 3:06 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 7th Nov 2018 3:05 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 7th Nov 2018 3:00 pm | 
                                            BUS | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 7th Nov 2018 2:59 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Co Ltd | 
                                        
                                                                            
                                            | 7th Nov 2018 2:58 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 7th Nov 2018 2:57 pm | 
                                            RNS | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 7th Nov 2018 2:54 pm | 
                                            BUS | 
                                            Form 8.3 - SHIRE PLC | 
                                        
                                                                            
                                            | 7th Nov 2018 2:53 pm | 
                                            RNS | 
                                            Form 8.3 - Shire Plc | 
                                        
                                                                            
                                            | 7th Nov 2018 2:38 pm | 
                                            RNS | 
                                            Form 8.3 - Shire Plc | 
                                        
                                                                            
                                            | 7th Nov 2018 2:30 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 7th Nov 2018 2:21 pm | 
                                            RNS | 
                                            Form 8.3 - [Shire Plc] | 
                                        
                                                                            
                                            | 7th Nov 2018 2:11 pm | 
                                            EQS | 
                                            Form 8.3 - The Vanguard Group, Inc.: Shire plc | 
                                        
                                                                            
                                            | 7th Nov 2018 2:07 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 7th Nov 2018 2:07 pm | 
                                            RNS | 
                                            Form 8.3 - Shire Plc | 
                                        
                                                                            
                                            | 7th Nov 2018 2:01 pm | 
                                            RNS | 
                                            Form 8 (DD) - Citibank NA London | 
                                        
                                                                            
                                            | 7th Nov 2018 1:58 pm | 
                                            RNS | 
                                            Form 8 (DD) - Citibank NA Switzerland | 
                                        
                                                                            
                                            | 7th Nov 2018 12:58 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Replacement of Shire | 
                                        
                                                                            
                                            | 7th Nov 2018 12:57 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Replacement of SHIRE | 
                                        
                                                                            
                                            | 7th Nov 2018 12:57 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Replacement of SHIRE | 
                                        
                                                                            
                                            | 7th Nov 2018 12:21 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 7th Nov 2018 11:38 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 7th Nov 2018 11:33 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) | 
                                        
                                                                            
                                            | 7th Nov 2018 11:18 am | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 7th Nov 2018 11:01 am | 
                                            RNS | 
                                            Form 8.5 - Shire plc | 
                                        
                                                                            
                                            | 7th Nov 2018 10:48 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI)- Shire Plc | 
                                        
                                                                            
                                            | 7th Nov 2018 10:26 am | 
                                            PRN | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 7th Nov 2018 10:17 am | 
                                            RNS | 
                                            Form 8.3 - SHIRE PLC | 
                                        
                                                                            
                                            | 7th Nov 2018 10:14 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) | 
                                        
                                                                            
                                            | 7th Nov 2018 10:11 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 7th Nov 2018 10:09 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 7th Nov 2018 10:08 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 7th Nov 2018 10:06 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI)- Shire plc |