| 13th Nov 2018 4:33 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI)- Shire plc AMENDMENT | 
                                        
                                                                            
                                            | 13th Nov 2018 4:33 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI)- Shire plc AMENDMENT | 
                                        
                                                                            
                                            | 13th Nov 2018 4:33 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI)- Shire plc AMENDMENT | 
                                        
                                                                            
                                            | 13th Nov 2018 3:26 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 13th Nov 2018 3:20 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 13th Nov 2018 3:04 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 13th Nov 2018 3:01 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 13th Nov 2018 3:00 pm | 
                                            BUS | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 13th Nov 2018 2:58 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 13th Nov 2018 2:33 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 13th Nov 2018 2:30 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 13th Nov 2018 2:27 pm | 
                                            RNS | 
                                            Form 8.3 - [Shire Plc] | 
                                        
                                                                            
                                            | 13th Nov 2018 2:27 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Replacement of SHIRE | 
                                        
                                                                            
                                            | 13th Nov 2018 2:26 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Replacement of SHIRE | 
                                        
                                                                            
                                            | 13th Nov 2018 2:23 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Replacement of SHIRE | 
                                        
                                                                            
                                            | 13th Nov 2018 2:08 pm | 
                                            EQS | 
                                            Form 8.3 - The Vanguard Group, Inc.: Shire plc | 
                                        
                                                                            
                                            | 13th Nov 2018 2:01 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 13th Nov 2018 1:58 pm | 
                                            RNS | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 13th Nov 2018 1:45 pm | 
                                            BUS | 
                                            Form 8.3 - Shire PLC - Amendment | 
                                        
                                                                            
                                            | 13th Nov 2018 1:42 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 13th Nov 2018 1:00 pm | 
                                            RNS | 
                                            Form 8.3 - Shire Plc | 
                                        
                                                                            
                                            | 13th Nov 2018 12:49 pm | 
                                            BUS | 
                                            Form 8.3 - SHIRE PLC | 
                                        
                                                                            
                                            | 13th Nov 2018 12:46 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 13th Nov 2018 12:43 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 13th Nov 2018 11:53 am | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 13th Nov 2018 11:27 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI)- Shire Plc | 
                                        
                                                                            
                                            | 13th Nov 2018 11:26 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Amendment | 
                                        
                                                                            
                                            | 13th Nov 2018 11:14 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 13th Nov 2018 11:04 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 13th Nov 2018 11:03 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 13th Nov 2018 11:03 am | 
                                            RNS | 
                                            Form 8 (DD) - Citibank NA Zurich | 
                                        
                                                                            
                                            | 13th Nov 2018 11:02 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 13th Nov 2018 11:01 am | 
                                            RNS | 
                                            Form 8 (DD) Citibank NA Jersey | 
                                        
                                                                            
                                            | 13th Nov 2018 10:54 am | 
                                            RNS | 
                                            Form 8 (DD) - Citibank NA London | 
                                        
                                                                            
                                            | 13th Nov 2018 10:52 am | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 13th Nov 2018 10:50 am | 
                                            RNS | 
                                            Form 8 (DD) Citibank NA Switzerland | 
                                        
                                                                            
                                            | 13th Nov 2018 10:50 am | 
                                            RNS | 
                                            Form 8.5 - Shire plc | 
                                        
                                                                            
                                            | 13th Nov 2018 10:36 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI)- Shire plc | 
                                        
                                                                            
                                            | 13th Nov 2018 10:27 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) | 
                                        
                                                                            
                                            | 13th Nov 2018 9:55 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) |