| 16th Nov 2018 3:56 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 16th Nov 2018 3:54 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 16th Nov 2018 3:31 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 16th Nov 2018 3:29 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 16th Nov 2018 3:26 pm | 
                                            RNS | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 16th Nov 2018 3:20 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 16th Nov 2018 3:20 pm | 
                                            BUS | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 16th Nov 2018 3:17 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 16th Nov 2018 3:00 pm | 
                                            BUS | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 16th Nov 2018 2:56 pm | 
                                            RNS | 
                                            Form 8.3 - [Shire Plc] | 
                                        
                                                                            
                                            | 16th Nov 2018 2:30 pm | 
                                            RNS | 
                                            Form 8.3 - Shire Plc | 
                                        
                                                                            
                                            | 16th Nov 2018 2:28 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 16th Nov 2018 2:26 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 16th Nov 2018 2:14 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Replacement of SHIRE | 
                                        
                                                                            
                                            | 16th Nov 2018 2:11 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Replacement of SHIRE | 
                                        
                                                                            
                                            | 16th Nov 2018 2:07 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Replacement of SHIRE | 
                                        
                                                                            
                                            | 16th Nov 2018 2:05 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 16th Nov 2018 1:56 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 16th Nov 2018 1:54 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 16th Nov 2018 1:36 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 16th Nov 2018 1:31 pm | 
                                            RNS | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 16th Nov 2018 12:07 pm | 
                                            BUS | 
                                            Form 8.3 - SHIRE PLC | 
                                        
                                                                            
                                            | 16th Nov 2018 12:04 pm | 
                                            BUS | 
                                            Form 8.3 - SHIRE PLC AMENDMENT | 
                                        
                                                                            
                                            | 16th Nov 2018 11:52 am | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 16th Nov 2018 11:29 am | 
                                            RNS | 
                                            Form 8.5 - Shire Plc | 
                                        
                                                                            
                                            | 16th Nov 2018 11:21 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI)- Shire Plc | 
                                        
                                                                            
                                            | 16th Nov 2018 10:56 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 16th Nov 2018 10:48 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) | 
                                        
                                                                            
                                            | 16th Nov 2018 10:46 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 16th Nov 2018 10:41 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 16th Nov 2018 10:41 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 16th Nov 2018 10:22 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI)- Shire plc | 
                                        
                                                                            
                                            | 16th Nov 2018 9:47 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 16th Nov 2018 9:46 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) | 
                                        
                                                                            
                                            | 16th Nov 2018 7:46 am | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 16th Nov 2018 7:00 am | 
                                            RNS | 
                                            Statement regarding Issuance of Senior Notes | 
                                        
                                                                            
                                            | 16th Nov 2018 7:00 am | 
                                            RNS | 
                                            Statement regarding Pricing of Senior Notes | 
                                        
                                                                            
                                            | 16th Nov 2018 7:00 am | 
                                            GNW | 
                                            Shire Announces New HELP Study(TM) Data for Lanadelumab in HAE at 2018 ACAAI Annual Scientific Meeting | 
                                        
                                                                            
                                            | 16th Nov 2018 7:00 am | 
                                            GNW | 
                                            Rule 2.9 Announcement | 
                                        
                                                                            
                                            | 15th Nov 2018 6:29 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Ltd |