| 14th Nov 2018 4:03 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 14th Nov 2018 4:02 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 14th Nov 2018 3:59 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 14th Nov 2018 3:40 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI)- Shire plc AMENDMENT | 
                                        
                                                                            
                                            | 14th Nov 2018 3:38 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Amendment | 
                                        
                                                                            
                                            | 14th Nov 2018 3:20 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 14th Nov 2018 3:17 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 14th Nov 2018 3:14 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 14th Nov 2018 3:00 pm | 
                                            BUS | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 14th Nov 2018 2:57 pm | 
                                            RNS | 
                                            Form 8.3 - Shire Plc | 
                                        
                                                                            
                                            | 14th Nov 2018 2:56 pm | 
                                            RNS | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 14th Nov 2018 2:56 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 14th Nov 2018 2:36 pm | 
                                            RNS | 
                                            Form 8.3 - Shire Plc | 
                                        
                                                                            
                                            | 14th Nov 2018 2:33 pm | 
                                            EQS | 
                                            Form 8.3 - The Vanguard Group, Inc.: Shire plc | 
                                        
                                                                            
                                            | 14th Nov 2018 2:32 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 14th Nov 2018 2:31 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 14th Nov 2018 2:30 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Replacement of SHIRE | 
                                        
                                                                            
                                            | 14th Nov 2018 2:12 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 14th Nov 2018 2:08 pm | 
                                            RNS | 
                                            Form 8.3 - [Shire Plc] | 
                                        
                                                                            
                                            | 14th Nov 2018 1:55 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 14th Nov 2018 1:53 pm | 
                                            BUS | 
                                            Form 8.3 - SHIRE PLC AMENDMENT | 
                                        
                                                                            
                                            | 14th Nov 2018 1:50 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 14th Nov 2018 1:44 pm | 
                                            BUS | 
                                            Form 8.3 - SHIRE PLC | 
                                        
                                                                            
                                            | 14th Nov 2018 12:09 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 14th Nov 2018 11:59 am | 
                                            RNS | 
                                            Form 8.5 - Shire Plc | 
                                        
                                                                            
                                            | 14th Nov 2018 11:38 am | 
                                            BUS | 
                                            Form 8.3 - SHIRE PLC - Amendment | 
                                        
                                                                            
                                            | 14th Nov 2018 11:34 am | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 14th Nov 2018 10:44 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI)- Shire Plc | 
                                        
                                                                            
                                            | 14th Nov 2018 10:41 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 14th Nov 2018 10:33 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 14th Nov 2018 10:31 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 14th Nov 2018 10:30 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 14th Nov 2018 10:22 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 14th Nov 2018 10:19 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) | 
                                        
                                                                            
                                            | 14th Nov 2018 10:11 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI)- Shire plc | 
                                        
                                                                            
                                            | 14th Nov 2018 9:54 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) | 
                                        
                                                                            
                                            | 14th Nov 2018 9:25 am | 
                                            RNS | 
                                            Form 8.3 - SHIRE PLC | 
                                        
                                                                            
                                            | 14th Nov 2018 7:00 am | 
                                            GNW | 
                                            Rule 2.9 Announcement | 
                                        
                                                                            
                                            | 13th Nov 2018 5:02 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Ltd | 
                                        
                                                                            
                                            | 13th Nov 2018 4:35 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI)- Shire plc AMENDMENT |