| 15th Nov 2018 3:47 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 15th Nov 2018 3:46 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 15th Nov 2018 3:20 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 15th Nov 2018 3:20 pm | 
                                            BUS | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 15th Nov 2018 3:11 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 15th Nov 2018 3:09 pm | 
                                            RNS | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 15th Nov 2018 3:08 pm | 
                                            RNS | 
                                            Form 8.3 - Shire Plc | 
                                        
                                                                            
                                            | 15th Nov 2018 3:00 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 15th Nov 2018 3:00 pm | 
                                            BUS | 
                                            Form 8.3 - Shire PLC | 
                                        
                                                                            
                                            | 15th Nov 2018 2:54 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 15th Nov 2018 2:53 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 15th Nov 2018 2:50 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 15th Nov 2018 2:49 pm | 
                                            EQS | 
                                            Form 8.3 - The Vanguard Group, Inc.: Shire plc | 
                                        
                                                                            
                                            | 15th Nov 2018 2:47 pm | 
                                            RNS | 
                                            Form 8.3 - [Shire Plc] | 
                                        
                                                                            
                                            | 15th Nov 2018 2:11 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 15th Nov 2018 2:11 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 15th Nov 2018 1:59 pm | 
                                            RNS | 
                                            Form 8 (DD) - Citibank NA Switzerland | 
                                        
                                                                            
                                            | 15th Nov 2018 1:53 pm | 
                                            RNS | 
                                            Form 8 (DD) Citibank NA London | 
                                        
                                                                            
                                            | 15th Nov 2018 1:51 pm | 
                                            RNS | 
                                            Form 8 (DD) - Citibank NA Jersey | 
                                        
                                                                            
                                            | 15th Nov 2018 1:35 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 15th Nov 2018 1:30 pm | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - Replacement of SHIRE | 
                                        
                                                                            
                                            | 15th Nov 2018 1:29 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 15th Nov 2018 1:15 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 15th Nov 2018 12:46 pm | 
                                            RNS | 
                                            Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                        
                                                                            
                                            | 15th Nov 2018 12:41 pm | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 15th Nov 2018 12:19 pm | 
                                            BUS | 
                                            FORM 8.3 - SHIRE PLC | 
                                        
                                                                            
                                            | 15th Nov 2018 11:44 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) | 
                                        
                                                                            
                                            | 15th Nov 2018 11:44 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) | 
                                        
                                                                            
                                            | 15th Nov 2018 11:41 am | 
                                            RNS | 
                                            Form 8.5 - Shire Plc | 
                                        
                                                                            
                                            | 15th Nov 2018 10:46 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 15th Nov 2018 10:44 am | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 15th Nov 2018 10:39 am | 
                                            RNS | 
                                            Form 8.5 (EPT/NON-RI)- Shire Plc | 
                                        
                                                                            
                                            | 15th Nov 2018 10:14 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) | 
                                        
                                                                            
                                            | 15th Nov 2018 10:09 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 15th Nov 2018 10:08 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 15th Nov 2018 10:07 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI)- Shire plc | 
                                        
                                                                            
                                            | 15th Nov 2018 10:06 am | 
                                            RNS | 
                                            Form 8.5 (EPT/RI) - SHIRE PLC | 
                                        
                                                                            
                                            | 15th Nov 2018 9:38 am | 
                                            RNS | 
                                            Form 8.3 - SHIRE PLC | 
                                        
                                                                            
                                            | 15th Nov 2018 8:28 am | 
                                            RNS | 
                                            Form 8.3 - Shire plc | 
                                        
                                                                            
                                            | 15th Nov 2018 7:00 am | 
                                            RNS | 
                                            Form 8.3 - Shire PLC |