| 25th Apr 2016 7:00 am | 
                                            RNS | 
                                            Replay for Analyst & Investor Conference Call | 
                                        
                                                                            
                                            | 22nd Apr 2016 7:00 am | 
                                            RNS | 
                                            Grant of Options | 
                                        
                                                                            
                                            | 21st Apr 2016 7:00 am | 
                                            RNS | 
                                            Annual Report and Accounts 2015 | 
                                        
                                                                            
                                            | 20th Apr 2016 7:00 am | 
                                            RNS | 
                                            Final Results | 
                                        
                                                                            
                                            | 18th Apr 2016 7:00 am | 
                                            RNS | 
                                            Results Conference Call Details | 
                                        
                                                                            
                                            | 14th Apr 2016 7:00 am | 
                                            RNS | 
                                            Senior Appointments | 
                                        
                                                                            
                                            | 23rd Mar 2016 7:00 am | 
                                            RNS | 
                                            Motif Bio to present at BIO-Europe Spring | 
                                        
                                                                            
                                            | 14th Mar 2016 7:00 am | 
                                            RNS | 
                                            Appointment of strategic adviser | 
                                        
                                                                            
                                            | 2nd Mar 2016 7:00 am | 
                                            RNS | 
                                            First patient dosed in iclaprim Phase 3 trials | 
                                        
                                                                            
                                            | 23rd Feb 2016 5:39 pm | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 22nd Feb 2016 7:00 am | 
                                            RNS | 
                                            Webcast on Combating antibiotic resistance | 
                                        
                                                                            
                                            | 25th Jan 2016 7:00 am | 
                                            RNS | 
                                            Appointments of U.S. finance adviser and auditor | 
                                        
                                                                            
                                            | 22nd Dec 2015 7:00 am | 
                                            RNS | 
                                            Exercise of Warrants | 
                                        
                                                                            
                                            | 15th Dec 2015 7:00 am | 
                                            RNS | 
                                            Iclaprim Clinical Trial Supplies Manufactured | 
                                        
                                                                            
                                            | 7th Dec 2015 7:00 am | 
                                            RNS | 
                                            Motif selected to present at Biotech Showcase | 
                                        
                                                                            
                                            | 24th Nov 2015 7:00 am | 
                                            RNS | 
                                            Receipt of FDA Concurrence | 
                                        
                                                                            
                                            | 11th Nov 2015 7:00 am | 
                                            RNS | 
                                            European Agreement for Iclaprim Development | 
                                        
                                                                            
                                            | 27th Oct 2015 7:00 am | 
                                            RNS | 
                                            Selected to Present at BIO-Europe 2015 | 
                                        
                                                                            
                                            | 21st Oct 2015 7:00 am | 
                                            RNS | 
                                            Exercise of Options | 
                                        
                                                                            
                                            | 16th Oct 2015 7:00 am | 
                                            RNS | 
                                            Leading CRO to Conduct Iclaprim Phase III Trials | 
                                        
                                                                            
                                            | 13th Oct 2015 7:00 am | 
                                            RNS | 
                                            Results of Two Posters on Iclaprim at ID Week 2015 | 
                                        
                                                                            
                                            | 12th Oct 2015 3:59 pm | 
                                            RNS | 
                                            Exercise of Options | 
                                        
                                                                            
                                            | 5th Oct 2015 4:41 pm | 
                                            RNS | 
                                            Directors Dealings | 
                                        
                                                                            
                                            | 29th Sep 2015 7:01 am | 
                                            RNS | 
                                            Presentation of Two Posters on Iclaprim | 
                                        
                                                                            
                                            | 23rd Sep 2015 3:04 pm | 
                                            RNS | 
                                            Issue of Shares for Exercised Warrants | 
                                        
                                                                            
                                            | 3rd Sep 2015 7:00 am | 
                                            RNS | 
                                            FDA Grants Fast Track Designation for Iclaprim | 
                                        
                                                                            
                                            | 2nd Sep 2015 7:00 am | 
                                            RNS | 
                                            Appointment of IR Adviser | 
                                        
                                                                            
                                            | 2nd Sep 2015 7:00 am | 
                                            RNS | 
                                            Participation at Upcoming Investor Events | 
                                        
                                                                            
                                            | 27th Aug 2015 7:01 am | 
                                            RNS | 
                                            Interims Results for the 6 months to 30 June 2015 | 
                                        
                                                                            
                                            | 24th Aug 2015 7:00 am | 
                                            RNS | 
                                            Potent Efficacy of Iclaprim Confirmed | 
                                        
                                                                            
                                            | 22nd Jul 2015 4:32 pm | 
                                            RNS | 
                                            FDA QIDP Designation | 
                                        
                                                                            
                                            | 22nd Jul 2015 7:00 am | 
                                            RNS | 
                                            Final condition of £22m placing satisfied | 
                                        
                                                                            
                                            | 20th Jul 2015 7:00 am | 
                                            RNS | 
                                            Exercise of Options | 
                                        
                                                                            
                                            | 17th Jul 2015 7:00 am | 
                                            RNS | 
                                            FDA QIDP Designation for Iclaprim for HABP | 
                                        
                                                                            
                                            | 15th Jul 2015 7:00 am | 
                                            RNS | 
                                            New Addition to Scientific Advisory Board | 
                                        
                                                                            
                                            | 10th Jul 2015 3:29 pm | 
                                            RNS | 
                                            Exercise of Options | 
                                        
                                                                            
                                            | 10th Jul 2015 1:37 pm | 
                                            RNS | 
                                            Result of General Meeting | 
                                        
                                                                            
                                            | 23rd Jun 2015 8:47 am | 
                                            RNS | 
                                            Partner Company raises £22 million | 
                                        
                                                                            
                                            | 23rd Jun 2015 7:00 am | 
                                            RNS | 
                                            Placing to raise £22 million and Change of Adviser | 
                                        
                                                                            
                                            | 9th Jun 2015 7:00 am | 
                                            RNS | 
                                            Audited Non-Statutory Financial Statements |