| 14th Apr 2020 4:41 pm | 
                                            RNS | 
                                            Second Price Monitoring Extn | 
                                        
                                                                            
                                            | 14th Apr 2020 4:37 pm | 
                                            RNS | 
                                            Price Monitoring Extension | 
                                        
                                                                            
                                            | 14th Apr 2020 1:21 pm | 
                                            RNS | 
                                            Stmnt re Share Price Movement | 
                                        
                                                                            
                                            | 9th Apr 2020 4:40 pm | 
                                            RNS | 
                                            Second Price Monitoring Extn | 
                                        
                                                                            
                                            | 9th Apr 2020 4:36 pm | 
                                            RNS | 
                                            Price Monitoring Extension | 
                                        
                                                                            
                                            | 9th Apr 2020 12:08 pm | 
                                            RNS | 
                                            Second Price Monitoring Extn | 
                                        
                                                                            
                                            | 9th Apr 2020 12:03 pm | 
                                            RNS | 
                                            Price Monitoring Extension | 
                                        
                                                                            
                                            | 7th Apr 2020 4:41 pm | 
                                            RNS | 
                                            Second Price Monitoring Extn | 
                                        
                                                                            
                                            | 7th Apr 2020 4:36 pm | 
                                            RNS | 
                                            Price Monitoring Extension | 
                                        
                                                                            
                                            | 19th Mar 2020 5:30 pm | 
                                            RNS | 
                                            Motif Bio | 
                                        
                                                                            
                                            | 19th Mar 2020 4:43 pm | 
                                            RNS | 
                                            Second Price Monitoring Extn | 
                                        
                                                                            
                                            | 19th Mar 2020 4:39 pm | 
                                            RNS | 
                                            Price Monitoring Extension | 
                                        
                                                                            
                                            | 18th Mar 2020 7:00 am | 
                                            RNS | 
                                            Corporate Update | 
                                        
                                                                            
                                            | 12th Mar 2020 4:42 pm | 
                                            RNS | 
                                            Second Price Monitoring Extn | 
                                        
                                                                            
                                            | 12th Mar 2020 4:36 pm | 
                                            RNS | 
                                            Price Monitoring Extension | 
                                        
                                                                            
                                            | 12th Mar 2020 12:02 pm | 
                                            RNS | 
                                            Price Monitoring Extension | 
                                        
                                                                            
                                            | 7th Feb 2020 4:35 pm | 
                                            RNS | 
                                            Price Monitoring Extension | 
                                        
                                                                            
                                            | 28th Jan 2020 4:40 pm | 
                                            RNS | 
                                            Second Price Monitoring Extn | 
                                        
                                                                            
                                            | 28th Jan 2020 4:35 pm | 
                                            RNS | 
                                            Price Monitoring Extension | 
                                        
                                                                            
                                            | 28th Jan 2020 7:00 am | 
                                            RNS | 
                                            Corporate Update | 
                                        
                                                                            
                                            | 22nd Jan 2020 4:40 pm | 
                                            RNS | 
                                            Second Price Monitoring Extn | 
                                        
                                                                            
                                            | 22nd Jan 2020 4:35 pm | 
                                            RNS | 
                                            Price Monitoring Extension | 
                                        
                                                                            
                                            | 17th Jan 2020 12:12 pm | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 16th Jan 2020 4:41 pm | 
                                            RNS | 
                                            Second Price Monitoring Extn | 
                                        
                                                                            
                                            | 16th Jan 2020 4:35 pm | 
                                            RNS | 
                                            Price Monitoring Extension | 
                                        
                                                                            
                                            | 16th Jan 2020 12:07 pm | 
                                            RNS | 
                                            Second Price Monitoring Extn | 
                                        
                                                                            
                                            | 16th Jan 2020 12:02 pm | 
                                            RNS | 
                                            Price Monitoring Extension | 
                                        
                                                                            
                                            | 14th Jan 2020 12:35 pm | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 10th Jan 2020 9:55 am | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 6th Jan 2020 4:40 pm | 
                                            RNS | 
                                            Second Price Monitoring Extn | 
                                        
                                                                            
                                            | 6th Jan 2020 4:35 pm | 
                                            RNS | 
                                            Price Monitoring Extension | 
                                        
                                                                            
                                            | 3rd Jan 2020 10:42 am | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 23rd Dec 2019 9:45 am | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 19th Dec 2019 4:29 pm | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 19th Dec 2019 4:25 pm | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 10th Dec 2019 7:00 am | 
                                            RNS | 
                                            Voluntary delisting from the NASDAQ Capital Market | 
                                        
                                                                            
                                            | 6th Dec 2019 11:14 am | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 29th Nov 2019 12:20 pm | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 29th Nov 2019 7:00 am | 
                                            RNS | 
                                            Total Voting Rights | 
                                        
                                                                            
                                            | 27th Nov 2019 7:00 am | 
                                            RNS | 
                                            ADS Program and Warrant Agent Agreement |