| 1st Nov 2018 4:35 pm | 
                                            RNS | 
                                            Price Monitoring Extension | 
                                        
                                                                            
                                            | 31st Oct 2018 7:00 am | 
                                            RNS | 
                                            Jefferies London Healthcare Conference | 
                                        
                                                                            
                                            | 30th Oct 2018 4:35 pm | 
                                            RNS | 
                                            Price Monitoring Extension | 
                                        
                                                                            
                                            | 16th Oct 2018 4:40 pm | 
                                            RNS | 
                                            Second Price Monitoring Extn | 
                                        
                                                                            
                                            | 16th Oct 2018 4:35 pm | 
                                            RNS | 
                                            Price Monitoring Extension | 
                                        
                                                                            
                                            | 3rd Oct 2018 8:01 am | 
                                            RNS | 
                                            Motif Bio Presents New Iclaprim Data at IDWeek | 
                                        
                                                                            
                                            | 28th Sep 2018 7:01 am | 
                                            RNS | 
                                            Motif Bio Notes Statement from Amphion Innovations | 
                                        
                                                                            
                                            | 25th Sep 2018 7:00 am | 
                                            RNS | 
                                            Half-year Report | 
                                        
                                                                            
                                            | 20th Sep 2018 7:00 am | 
                                            RNS | 
                                            Upcoming Scientific Conferences | 
                                        
                                                                            
                                            | 5th Sep 2018 7:00 am | 
                                            RNS | 
                                            Iclaprim Data presented at ESCMID/ASM Conference | 
                                        
                                                                            
                                            | 29th Aug 2018 4:35 pm | 
                                            RNS | 
                                            Price Monitoring Extension | 
                                        
                                                                            
                                            | 21st Aug 2018 7:15 am | 
                                            RNS | 
                                            Motif Bio notes statement from Amphion Innovations | 
                                        
                                                                            
                                            | 17th Aug 2018 7:00 am | 
                                            RNS | 
                                            Iclaprim Data at ESCMID/ASM Conference | 
                                        
                                                                            
                                            | 14th Aug 2018 4:49 pm | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 14th Aug 2018 4:48 pm | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 14th Aug 2018 7:00 am | 
                                            RNS | 
                                            FDA Acceptance of New Drug Application | 
                                        
                                                                            
                                            | 9th Aug 2018 7:00 am | 
                                            RNS | 
                                            Investor Events in August and September | 
                                        
                                                                            
                                            | 8th Aug 2018 7:00 am | 
                                            RNS | 
                                            Notice of Allowance for Two U.S. Iclaprim Patents | 
                                        
                                                                            
                                            | 2nd Aug 2018 4:35 pm | 
                                            RNS | 
                                            Price Monitoring Extension | 
                                        
                                                                            
                                            | 3rd Jul 2018 4:48 pm | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 3rd Jul 2018 7:00 am | 
                                            RNS | 
                                            Directorate Change | 
                                        
                                                                            
                                            | 26th Jun 2018 11:57 am | 
                                            RNS | 
                                            Exercise of Stock Options | 
                                        
                                                                            
                                            | 19th Jun 2018 1:58 pm | 
                                            RNS | 
                                            Result of AGM | 
                                        
                                                                            
                                            | 14th Jun 2018 7:00 am | 
                                            RNS | 
                                            Motif Bio Submits NDA for Iclaprim | 
                                        
                                                                            
                                            | 11th Jun 2018 11:41 am | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 11th Jun 2018 7:00 am | 
                                            RNS | 
                                            Motif Bio present New Iclaprim Data at ASM Microbe | 
                                        
                                                                            
                                            | 8th Jun 2018 5:08 pm | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 31st May 2018 7:00 am | 
                                            RNS | 
                                            Jefferies Global Healthcare Conference | 
                                        
                                                                            
                                            | 25th May 2018 4:04 pm | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 24th May 2018 4:39 pm | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 23rd May 2018 5:42 pm | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 23rd May 2018 7:00 am | 
                                            RNS | 
                                            Motif Bio notes statement from Amphion Innovations | 
                                        
                                                                            
                                            | 17th May 2018 2:24 pm | 
                                            RNS | 
                                            Result of Placing | 
                                        
                                                                            
                                            | 17th May 2018 9:55 am | 
                                            RNS | 
                                            Proposed Placing to raise approximately £10m | 
                                        
                                                                            
                                            | 9th May 2018 7:00 am | 
                                            RNS | 
                                            Appointment of Vice President,Clinical Development | 
                                        
                                                                            
                                            | 8th May 2018 7:00 am | 
                                            RNS | 
                                            Motif Bio to Present Iclaprim Data at ASM Microbe | 
                                        
                                                                            
                                            | 1st May 2018 7:00 am | 
                                            RNS | 
                                            REVIVE-2 Study Results Published in Journal | 
                                        
                                                                            
                                            | 19th Apr 2018 7:00 am | 
                                            RNS | 
                                            New Iclaprim Data being Presented at ECCMID 2018 | 
                                        
                                                                            
                                            | 17th Apr 2018 4:40 pm | 
                                            RNS | 
                                            Second Price Monitoring Extn | 
                                        
                                                                            
                                            | 17th Apr 2018 4:35 pm | 
                                            RNS | 
                                            Price Monitoring Extension |