| 17th Apr 2018 7:00 am | 
                                            RNS | 
                                            Posting of UK Annual Report and Notice of AGM | 
                                        
                                                                            
                                            | 11th Apr 2018 2:30 pm | 
                                            RNS | 
                                            Iclaprim Abstracts for ECCMID 2018 Now Online | 
                                        
                                                                            
                                            | 10th Apr 2018 7:00 am | 
                                            RNS | 
                                            Fiscal Year 2017 Results | 
                                        
                                                                            
                                            | 3rd Apr 2018 3:29 pm | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 3rd Apr 2018 7:00 am | 
                                            RNS | 
                                            Initiation of NDA Rolling Submission for Iclaprim | 
                                        
                                                                            
                                            | 20th Mar 2018 7:00 am | 
                                            RNS | 
                                            Motif Bio Update on NDA Submission for Iclaprim | 
                                        
                                                                            
                                            | 19th Mar 2018 7:00 am | 
                                            RNS | 
                                            Motif Bio to present at upcoming conferences | 
                                        
                                                                            
                                            | 13th Mar 2018 3:55 pm | 
                                            RNS | 
                                            Change of Registered Office | 
                                        
                                                                            
                                            | 7th Mar 2018 12:29 pm | 
                                            RNS | 
                                            Exercise of Warrants | 
                                        
                                                                            
                                            | 1st Mar 2018 7:00 am | 
                                            RNS | 
                                            Grant of share options to senior management | 
                                        
                                                                            
                                            | 21st Feb 2018 7:00 am | 
                                            RNS | 
                                            Motif Bio to Present Iclaprim Data at ECCMID 2018 | 
                                        
                                                                            
                                            | 19th Feb 2018 12:53 pm | 
                                            RNS | 
                                            Exercise of Warrants | 
                                        
                                                                            
                                            | 2nd Feb 2018 3:00 pm | 
                                            RNS | 
                                            Appointment of Interim Chief Financial Officer | 
                                        
                                                                            
                                            | 29th Jan 2018 12:07 pm | 
                                            RNS | 
                                            Second Price Monitoring Extn | 
                                        
                                                                            
                                            | 29th Jan 2018 12:02 pm | 
                                            RNS | 
                                            Price Monitoring Extension | 
                                        
                                                                            
                                            | 19th Jan 2018 7:00 am | 
                                            RNS | 
                                            Filing of U.S. Shelf Registration | 
                                        
                                                                            
                                            | 16th Jan 2018 7:00 am | 
                                            RNS | 
                                            Motif Bio Receives Award from CF Foundation | 
                                        
                                                                            
                                            | 12th Jan 2018 3:12 pm | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 11th Jan 2018 3:07 pm | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 8th Jan 2018 3:23 pm | 
                                            RNS | 
                                            Exercise of Warrants | 
                                        
                                                                            
                                            | 5th Jan 2018 7:00 am | 
                                            RNS | 
                                            Motif Bio to participate in panel discussion | 
                                        
                                                                            
                                            | 22nd Dec 2017 7:01 am | 
                                            RNS | 
                                            Notes statement from Amphion Innovations | 
                                        
                                                                            
                                            | 21st Dec 2017 1:00 pm | 
                                            RNS | 
                                            REVIVE-1 additional results published | 
                                        
                                                                            
                                            | 14th Dec 2017 7:00 am | 
                                            RNS | 
                                            Filing of SEC Form F-3 | 
                                        
                                                                            
                                            | 28th Nov 2017 6:24 pm | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 17th Nov 2017 7:00 am | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 17th Nov 2017 7:00 am | 
                                            RNS | 
                                            Exercise of Warrants | 
                                        
                                                                            
                                            | 15th Nov 2017 7:00 am | 
                                            RNS | 
                                            Secures up to US$20 million debt financing | 
                                        
                                                                            
                                            | 9th Nov 2017 2:40 pm | 
                                            RNS | 
                                            Exercise of Warrants | 
                                        
                                                                            
                                            | 6th Nov 2017 12:29 pm | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 18th Oct 2017 7:00 am | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 6th Oct 2017 1:20 pm | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 6th Oct 2017 7:00 am | 
                                            RNS | 
                                            New Pre-Clinical Data for Iclaprim at IDWeek 2017 | 
                                        
                                                                            
                                            | 5th Oct 2017 9:57 am | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 4th Oct 2017 7:00 am | 
                                            RNS | 
                                            Positive Topline Results in Phase Three Study | 
                                        
                                                                            
                                            | 29th Sep 2017 7:00 am | 
                                            RNS | 
                                            Half-year Report | 
                                        
                                                                            
                                            | 25th Sep 2017 7:01 am | 
                                            RNS | 
                                            Holding(s) in Company | 
                                        
                                                                            
                                            | 15th Sep 2017 2:07 pm | 
                                            RNS | 
                                            iclaprim granted Orphan Drug Designation by US FDA | 
                                        
                                                                            
                                            | 8th Sep 2017 1:00 pm | 
                                            RNS | 
                                            Host Investor and Analyst Event on September 20 | 
                                        
                                                                            
                                            | 31st Aug 2017 1:00 pm | 
                                            RNS | 
                                            Company to present at conferences in September |