KOL presentations on Creo Core Products at DDW

Creo Medical Group plc

("Creo", the "Company" or the "Group")

KOL presentations on Creo Core Products at DDW

Data presentations at Digestive Disease Week further validate Creo Medical's endoscopic devices

Creo Medical Group plc (AIM: CREO), the medical device company focused on the emerging field of minimally invasive surgical endoscopy for pre-cancer and cancer patients, announces that it will be attending the Digestive Disease Week ("DDW") 2026 conference in Chicago, IL, taking place between 2-5 May 2026 (booth 4536).

The conference will feature a range of presentations from Key Opinion Leaders ("KOLs") showcasing minimally invasive endoscopy procedures, with certain KOLs presenting studies further validating Creo Medical's endoscopic devices. Presentations include:

Zacharias P. Tsiamoulos, Director of Endoscopic Microsurgery Department at Hygeia Hospital, will present data as part of the ASGE World Cup displaying that sequential intermuscular and full thickness dissection with bipolar/microwave-assisted endoscopic submucosal dissection ("ESD") resulted in R0 resection and no postoperative complications. This study is significant in further validating Creo Medical's CROMA Advanced Energy Platform, powered by Kamaptive, which combines advanced bipolar radiofrequency and microwave energy to deliver safe and precise controlled coagulation.

Theodoros Alexopoulos, East Kent Hospitals University NHS Foundation Trust, will present prospective data from over 600 Speedboat™ assisted ESD cases for colorectal cancer, challenging the established 1mm cancer-free vertical margin threshold.

Eduardo Albéniz, Gastroenterology Specialist at Complejo Hospitalario de Navarra, will also be presenting an early experience study of bipolar knife peroral endoscopic myotomy ("POEM") using Speedboat™ and the CROMA Advanced Energy Platform. The study showed 100% technical success across 75 patients and demonstrates the potential benefits of POEM procedures with Speedboat and reduced instrument exchanges.

For more information about the event, please see the DDW website here.

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About Creo Medical

Creo is a medical device company focused on the development and commercialisation of minimally invasive electrosurgical devices, bringing advanced energy to endoscopy.

The Company's vision is to improve patient outcomes through the development and commercialisation of a suite of electrosurgical medical devices, each enabled by CROMA, powered by Kamaptive. The Group has developed the CROMA powered by Kamaptive full-spectrum adaptive technology to optimise surgical capability and patient outcomes. Kamaptive is a seamless, intuitive integration of multi-modal energy sources, optimised to dynamically adapt to patient tissue during procedures such as resection, dissection, coagulation, and ablation of tissue. Kamaptive technology provides clinicians with increased flexibility, precision and controlled surgical solutions. CROMA currently delivers bipolar radiofrequency ("RF") energy for precise localised cutting and focused high frequency microwave ("MW") energy for controlled coagulation and ablation via a single accessory port. This technology, combined with the Group's range of patented electrosurgical devices, is designed to provide clinicians with flexible, accurate and controlled clinical solutions. The Directors believe the Company's technology can impact the landscape of surgery and endoscopy by providing a safer, less invasive and more cost-efficient option for procedures.

For more information, please refer to the website www.creomedical.com