Issue of Equity - Updated number of shares to be issued

11 November 2026

THIS ANNOUNCEMENT CONTAINS INSIDE INFORMATION

Pensana Plc("Pensana" or the "Company")

Issue of Equity

Issue of Equity – Updated number of shares to be issued

Pensana Plc (LSE: PRE) (the “Company”) announces that, further to the Issue of Equity announcement released on 10 November 2026, a total of 454,000 New Ordinary Shares are expected to be admitted on the LSE on or about 08:00 on 16 November 2026. These shares rank pari passu with the existing Ordinary Shares in issue.

Following this issue, the Company’s issued share capital consists of 353,969,226 Ordinary Shares. No shares are held in treasury. Therefore, the total number of voting rights of the Company is 353,969,226.

The above figure may be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change in their interest in, the Company under the Financial Conduct Authority’s Disclosure and Transparency Rules.

The Company will update the market as to the application and admission of the remaining 4,546,000 New Ordinary Shares referred to in the Issue of Equity announcement of 10 November 2026.

The information contained within this announcement is considered by the Company to constitute inside information as stipulated under the Market Abuse Regulations (EU) No.596/2014. Upon the publication of this announcement via a Regulatory Information Service, this inside information will be considered to be in the public domain. The person responsible for arranging for the release of this announcement on behalf of the Company is Paul Atherley (Chairman).

-ENDS-

For further information, please contact: Shareholder/analyst enquiries:

Pensana Plc

Paul Atherley, Chairman [email protected] Tim George, Chief Executive OfficerRob Kaplan, Chief Financial Officer