Holding(s) in Company

TR-1: Notifications of Major Interests in Shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

York Pharma Plc

2. Reason for notification (yes/no)

An acquisition or disposal of voting rights:

An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached:

An event changing the breakdown of voting rights:

X

Other (please specify):

3. Full name of person(s) subject to notification obligation:

Barclays PLC

4. Full name of shareholder(s) (if different from 3):

Barclays Stockbrokers Ltd

5. Date of transaction (and date on which the threshold is crossed or reached if different):

28 Nov 2008

6. Date on which issuer notified:

1 Dec 2008

7. Threshold(s) that is/are crossed or reached:

7% to 6%

8. Notified Details

A: Voting rights attached to shares

Class/Type of Shares

If possible using the ISN CODE

Situation previous to the Triggering transaction

Resulting situation after the triggering transaction

Number of Shares

Number of Voting Rights

Number of Shares

Number of Voting Rights

% of voting rights

Direct

Indirect

Direct

Indirect

GB00B00QHC86

4,174,334

4,174,334

4,174,334

0

4,174,334

0.00

6.86

B: Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Expiration date

Exercise / Conversion Period / Date

Number of voting rights that may be acquired if the instrument is exercised / converted

% of voting rights

Total (A+B)

Number of voting rights

% of voting rights

4,174,334

6.86

9. Chain of controlled undertakings through which the voting rights and /or the financial instruments are effectively held, if applicable:

Barclays Stockbrokers Ltd

Proxy Voting:

10. Name of proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

14. Contact name:

Geoff Smith

15. Contact telephone name:

020 7116 2913