Holding(s) in Company

20 MARCH 2017

1. Identity of the issuer or the underlying issuerof existing shares to which voting rights areattached: ii

Immupharma plc

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

√

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify):

CHANGE TO THE NUMBER OF VOTING RIGHTS IN ISSUE, FOLLOWING THE RECENT PLACING

√

3. Full name of person(s) subject to thenotification obligation: iii

Aviva plc & its subsidiaries

4. Full name of shareholder(s)  (if different from 3.):iv

Registered Holder:

Chase (GA Group) Nominees Limited : 7,361,243*

HSBC Global Custody Nominee (UK) Limited : 1,606,013*

State Street Nominees Limited : 200,974*

*denotes direct interest

Chase (GA Group) Nominees Limited :  409,378

Chase Nominees Limited : 248,294

Vidacos Nominees Limited : 436,614

5. Date of the transaction and date onwhich the threshold is crossed orreached: v

16 March 2017

6. Date on which issuer notified:

17 March 2017

7. Threshold(s) that is/are crossed orreached: vi, vii

7% to 6% Change at Direct Interest Level (Box 8A)

8. Notified details:

A: Voting rights attached to shares viii, ix

Class/type ofshares

if possible usingthe ISIN CODE

Situation previousto the triggeringtransaction

Resulting situation after the triggering transaction

NumberofShares

NumberofVotingRights

Numberof shares

Number of votingrights

% of voting rights x

Direct

Direct xi

Indirect xii

Direct

Indirect

Ordinary Shares

GB0033711010

11,169,942

11,169,942

10,262,516

9,168,230

1,094,286

6.92%

0.83%

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Expirationdate xiii

Exercise/Conversion Period xiv

Number of votingrights that may beacquired if theinstrument isexercised/ converted.

% of votingrights

RIGHT TO RECALL LOANED SHARES

N/A

N/A

18,000*

*DIRECT INTEREST

0.01%

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi

Resulting situation after the triggering transaction

Type of financialinstrument

Exercise price

Expiration date xvii

Exercise/Conversion period xviii

Number of voting rights instrument refers to

% of voting rights xix, xx

Total (A+B+C)

Number of voting rights

Percentage of voting rights

10,280,516

7.76%

9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: xxi

The voting rights are managed and controlled by Aviva Investors Global Services Limited, with the following chain of controlled undertakings:-

Aviva Investors Global Services Limited:

· Aviva plc (Parent Company)

· Aviva Group Holdings Limited (wholly owned subsidiary of Aviva plc)

· Aviva Investors Holdings Limited (wholly owned subsidiary of Aviva Group Holdings Limited)

· Aviva Investors Global Services Limited (wholly owned subsidiary of Aviva Investors Holdings Limited)

Proxy Voting:

10. Name of the proxy holder:

See Section 4

11. Number of voting rights proxy holder will ceaseto hold:

12. Date on which proxy holder will cease to holdvoting rights:

13. Additional information:

Figures are based the revised total number of voting rights of 132,522,985 as per the recent £4.1 Million Fund Raise via Accelerated Bookbuild announcement of 10 March 2017.

14. Contact name:

Neil Whittaker, Aviva plc

15. Contact telephone number:

 01603 684420

For further information please contact: