| 23rd Jan 2013 7:00 am | RNS | PretzelFlex 3mm FDA approval | 
                                                                            
                                            | 22nd Jan 2013 7:00 am | RNS | Second order of 5mm PretzelFlex® shipped | 
                                                                            
                                            | 17th Jan 2013 7:00 am | RNS | SI to benefit from £5.05m RGF Grant | 
                                                                            
                                            | 10th Jan 2013 7:00 am | RNS | Directors shareholding | 
                                                                            
                                            | 18th Dec 2012 9:24 am | RNS | Directors' dealings and issue of equity | 
                                                                            
                                            | 18th Dec 2012 7:00 am | RNS | Appointments to the Clinical Advisory Board | 
                                                                            
                                            | 29th Oct 2012 7:00 am | RNS | First PretzelFlex® orders shipped to CareFusion | 
                                                                            
                                            | 11th Oct 2012 7:00 am | RNS | Successful exhibition at ISHA in the US | 
                                                                            
                                            | 18th Sep 2012 7:00 am | RNS | Half Yearly Report | 
                                                                            
                                            | 4th Sep 2012 7:00 am | RNS | Notice of Results | 
                                                                            
                                            | 30th Aug 2012 2:14 pm | RNS | Holding(s) in Company | 
                                                                            
                                            | 26th Jun 2012 7:00 am | RNS | Grant of options | 
                                                                            
                                            | 19th Jun 2012 3:33 pm | RNS | Result of AGM | 
                                                                            
                                            | 19th Jun 2012 7:00 am | RNS | AGM Statement | 
                                                                            
                                            | 18th Jun 2012 7:00 am | RNS | OEM distribution agreement with CareFusion | 
                                                                            
                                            | 31st May 2012 7:00 am | RNS | UK distribution agreement | 
                                                                            
                                            | 25th May 2012 11:58 am | RNS | Directorate Change | 
                                                                            
                                            | 22nd May 2012 7:00 am | RNS | Publication of Annual Report and Notice of AGM | 
                                                                            
                                            | 1st May 2012 7:00 am | RNS | Investor site visit | 
                                                                            
                                            | 24th Apr 2012 7:00 am | RNS | Final Results | 
                                                                            
                                            | 20th Apr 2012 7:00 am | RNS | Notice of Results | 
                                                                            
                                            | 15th Mar 2012 7:00 am | RNS | FDA 510(k) approval for reusable PretzelFlexT | 
                                                                            
                                            | 23rd Feb 2012 4:54 pm | RNS | Holding(s) in Company | 
                                                                            
                                            | 17th Feb 2012 4:36 pm | RNS | Director/PDMR Shareholding | 
                                                                            
                                            | 14th Feb 2012 5:49 pm | RNS | Issue of Equity | 
                                                                            
                                            | 1st Feb 2012 7:00 am | RNS | Re: US contract and FDA approval | 
                                                                            
                                            | 23rd Jan 2012 7:01 am | RNS | Trading Statement | 
                                                                            
                                            | 2nd Dec 2011 7:00 am | RNS | Investor Site Visit | 
                                                                            
                                            | 3rd Nov 2011 7:00 am | RNS | Issue of Equity | 
                                                                            
                                            | 1st Nov 2011 7:00 am | RNS | Confirmation of successful RGF bid | 
                                                                            
                                            | 21st Sep 2011 4:49 pm | RNS | Issue of Equity | 
                                                                            
                                            | 14th Sep 2011 7:00 am | RNS | Half Yearly Report | 
                                                                            
                                            | 1st Sep 2011 5:23 pm | RNS | Holding(s) in Company | 
                                                                            
                                            | 1st Sep 2011 7:00 am | RNS | Re Agreement | 
                                                                            
                                            | 1st Sep 2011 7:00 am | RNS | Agreement with Surgical Innovations Group | 
                                                                            
                                            | 24th Aug 2011 7:00 am | RNS | Notice of Results | 
                                                                            
                                            | 22nd Jul 2011 7:00 am | RNS | Re Agreement | 
                                                                            
                                            | 20th Jun 2011 2:42 pm | RNS | Result of AGM | 
                                                                            
                                            | 20th Jun 2011 7:00 am | RNS | AGM Statement | 
                                                                            
                                            | 13th Jun 2011 5:08 pm | RNS | Holding(s) in Company |