| 8th Jan 2019 5:30 pm | GNW | Director/PDMR Shareholding | 
                                                                            
                                            | 8th Jan 2019 3:20 pm | RNS | Form 8.3 - Shire plc | 
                                                                            
                                            | 8th Jan 2019 3:19 pm | RNS | Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                                                            
                                            | 8th Jan 2019 3:13 pm | RNS | Form 8.3 - Shire plc | 
                                                                            
                                            | 8th Jan 2019 3:07 pm | RNS | Form 8.5 (EPT/NON-RI) | 
                                                                            
                                            | 8th Jan 2019 2:28 pm | RNS | Form 8.5 (EPT/RI) - Replacement of Shire | 
                                                                            
                                            | 8th Jan 2019 2:23 pm | RNS | Form 8.5 (EPT/RI) - Replacement of Shire | 
                                                                            
                                            | 8th Jan 2019 2:21 pm | RNS | Form 8.5 (EPT/RI) - Replacement of Shire | 
                                                                            
                                            | 8th Jan 2019 1:57 pm | RNS | Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                                                            
                                            | 8th Jan 2019 1:27 pm | RNS | Form 8.3 - Shire plc | 
                                                                            
                                            | 8th Jan 2019 12:31 pm | RNS | Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                                                            
                                            | 8th Jan 2019 12:29 pm | RNS | Form 8.3 - Takeda Pharmaceutical | 
                                                                            
                                            | 8th Jan 2019 12:27 pm | RNS | Form 8.3 - Shire plc | 
                                                                            
                                            | 8th Jan 2019 11:42 am | RNS | Form 8.5 (EPT/NON-RI) | 
                                                                            
                                            | 8th Jan 2019 11:33 am | RNS | Form 8.5 (EPT/NON-RI)- Shire Plc | 
                                                                            
                                            | 8th Jan 2019 10:49 am | RNS | Form 8.5 (EPT/RI) | 
                                                                            
                                            | 8th Jan 2019 10:41 am | RNS | Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                                                            
                                            | 8th Jan 2019 10:26 am | RNS | Form 8.5 (EPT/RI)- Shire plc | 
                                                                            
                                            | 8th Jan 2019 9:51 am | RNS | Form 8.3 - Shire Plc | 
                                                                            
                                            | 8th Jan 2019 8:44 am | RNS | Form 8.5 (EPT/RI) - SHIRE PLC | 
                                                                            
                                            | 8th Jan 2019 7:00 am | RNS | Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                                                            
                                            | 8th Jan 2019 7:00 am | GNW | Scheme becomes effective | 
                                                                            
                                            | 7th Jan 2019 5:00 pm | GNW | Holding(s) in Company | 
                                                                            
                                            | 7th Jan 2019 3:42 pm | RNS | Form 8.5 (EPT/RI) - Amendment | 
                                                                            
                                            | 7th Jan 2019 3:20 pm | RNS | Form 8.3 - Shire plc | 
                                                                            
                                            | 7th Jan 2019 3:02 pm | RNS | Form 8.3 - Shire plc | 
                                                                            
                                            | 7th Jan 2019 3:00 pm | RNS | Form 8.5 (EPT/NON-RI) | 
                                                                            
                                            | 7th Jan 2019 3:00 pm | RNS | Form 8.3 - Shire plc | 
                                                                            
                                            | 7th Jan 2019 2:59 pm | RNS | Form 8.3 - Takeda Pharmaceutical | 
                                                                            
                                            | 7th Jan 2019 2:50 pm | PRN | Form 8.3 - Shire Plc | 
                                                                            
                                            | 7th Jan 2019 2:49 pm | RNS | Form 8.3 - Shire plc | 
                                                                            
                                            | 7th Jan 2019 2:47 pm | RNS | Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                                                            
                                            | 7th Jan 2019 2:45 pm | BUS | Form 8.3 - Shire plc | 
                                                                            
                                            | 7th Jan 2019 1:55 pm | RNS | Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                                                            
                                            | 7th Jan 2019 1:54 pm | RNS | Form 8.3 - Shire plc | 
                                                                            
                                            | 7th Jan 2019 1:39 pm | RNS | Form 8.3 - [Shire Plc] | 
                                                                            
                                            | 7th Jan 2019 1:32 pm | RNS | Form 8.5 (EPT/RI) - Replacement of Shire | 
                                                                            
                                            | 7th Jan 2019 1:29 pm | RNS | Form 8.5 (EPT/RI) - Replacement of Shire | 
                                                                            
                                            | 7th Jan 2019 12:57 pm | RNS | Form 8.3 - Takeda Pharmaceutical Company Limited | 
                                                                            
                                            | 7th Jan 2019 12:56 pm | RNS | Form 8.3 - Shire plc |