Verseon presents new DME efficacy results

Press release October 2, 2017

Verseon Corporation

("Verseon" or the "Company")

Verseon presents new efficacy results in diabetic macular edema program at Targeting Ocular Disorders conference

Fremont, Calif.-Verseon, a technology-based pharmaceutical company employing a computer-driven platform to develop a diverse drug pipeline, presented promising preclinical efficacy results on its plasma kallikrein inhibitors for the treatment of diabetic macular edema (DME) at the Targeting Ocular Disorders conference in Boston last week. By developing drugs for either eye-drop or oral administration, the Company aims to provide much-needed alternatives to the current standard of recurring intravitreal injections (anti-VEGF agents or corticosteroids) and laser treatments.

When administered as single eye drops in intraocular pharmacokinetic studies, a number of Verseon's plasma kallikrein inhibitors reach significant concentrations in the relevant tissues of the eye. Other candidates show good oral exposure and bioavailability.

At the Targeting Ocular Disorders conference, Verseon's Dr. Timothy Shiau reported on a comprehensive in vivo efficacy model in which the Company's drug candidates reduce leakage into the retina and restore mean circulation times. In addition to previously disclosed results showing efficacy after infusion-pump dosing, Dr. Shiau presented new data demonstrating that certain Verseon inhibitors are efficacious when dosed orally. Both preclinical findings firmly establish that Verseon's drug candidates successfully slow the progression of DME.

 "Plasma kallikrein inhibitors are promising candidates for slowing and potentially reversing DME," said Dr. Shiau. "We are excited about our recent results, which show that within our novel class of plasma kallikrein inhibitors, we have multiple candidates with excellent profiles for topical ophthalmic administration and others suitable for oral dosing."

About Verseon's diabetic macular edema program

Verseon has developed a new class of potent, selective compounds for the treatment of diabetic macular edema. The Company's plasma kallikrein inhibitors target a validated pathway addressing an underlying cause of the disease. In preclinical testing, Verseon's inhibitors show favorable biochemical properties permitting either topical (eye drop) or oral administration. Several lead candidates have demonstrated efficacy after infusion pump dosing, while others are efficacious when administered orally.

About Verseon

Verseon Corporation (www.verseon.com, AIM: VSN) is a technology-based pharmaceutical company that employs its proprietary, computational drug discovery platform to develop novel therapeutics that are unlikely to be found using conventional methods. The Company is applying its platform to a growing drug pipeline and currently has four active drug programs in the areas of anticoagulation, diabetic macular edema, hereditary angioedema, and oncology.

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