Updated Rule 2.10 Announcement

NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION (IN WHOLE OR IN PART) IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OF SUCH JURISDICTION. Updated Rule 2.10 Announcement Dublin, Ireland - June 26, 2014 - In accordance with Rule 2.10 of the Code,Shire (LSE: SHP, NASDAQ: SHPG) confirms that as at close of business on 25 June2014, it had in issue 589,262,359 ordinary shares of 5 pence each (excludingordinary shares held in treasury), with ISIN Number JE00B2QKY057, which carryvoting rights of one vote per share. Shire has an American Depositary Share ("ADS") programme for which Citibank,N.A. acts as Depositary. One ADS represents three ordinary shares of 5 penceeach, with ISIN Number US82481R1068. The ADSs trade on the NASDAQ Global SelectMarket. For further information please contact: Media Stephanie Fagan [email protected] +1 201 572 9581 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Neuroscience, Rare Diseases,Gastrointestinal, and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmology. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com