Updated Rule 2.10 Announcement

NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION (IN WHOLE OR IN PART) IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OF SUCH JURISDICTION. Updated Rule 2.10 Announcement Dublin, Ireland - August 1, 2014 - In accordance with Rule 2.10 of The CityCode on Takeovers and Mergers, Shire plc (LSE: SHP, NASDAQ: SHPG) confirmsthat, as at close of business on July 31, 2014, it had in issue 589,538,765ordinary shares of 5 pence each (excluding ordinary shares held in treasury),with ISIN JE00B2QKY057, which carry voting rights of one vote per share. Shire plc has an American Depositary Receipt program for which Citibank, N.A.acts as Depositary. One American Depositary Share ("ADS") represents threeordinary shares of 5 pence each, with ISIN US82481R1068. The ADSs trade on theNASDAQ Global Select Market. For further information please contact: Investor Relations Jeff Poulton [email protected] +1 781 482 0945 Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Neuroscience, Rare Diseases,Gastrointestinal, and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmology. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com