Transaction in Own Shares

SHIRE PLC - Transaction in Own Shares

PR Newswire

London, April 2

Transaction in Own Shares

April 3, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"), announcesthat in accordance with the authority granted by shareholders at the Company'sAnnual General Meeting on April 24, 2012 it purchased 108,500 of its ordinaryshares of 5 pence each ("Ordinary Shares") on April 2, 2013 through both directpurchases of Ordinary Shares and through the purchase of Ordinary Sharesunderlying ADRs. The highest and lowest price paid for the directly acquiredOrdinary Shares was 2007.00 pence per share and 1980.00 pence per sharerespectively and for those Ordinary Shares acquired through the purchase ofADRs was 3000.00 cents per share and 2981.33 cents per share respectively.

The purchased shares will be held as treasury shares. Following the abovepurchase, the Company holds 6,115,688 Ordinary Shares as treasury shares andhas 556,690,622 Ordinary Shares in issue (excluding treasury shares).

The purchases were made by an independent third party which makes its tradingdecisions independently of, and uninfluenced by the Company. The independenceof the third party enables the Company to continue to purchase Ordinary Shares(including Ordinary Shares underlying ADRs) during close periods and otherprohibited periods, should they arise. The third party has been appointed bythe Company to make purchases to December 31, 2013.

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Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients' needs, we develop and providehealthcare in the areas of:

as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value forpatients, physicians, policymakers, payors and our shareholders.

www.shire.com

www.shire.com