Transaction in Own Shares

REPURCHASE OF SHARES IN ASTRAZENECA PLC

AstraZeneca PLC announced that on 21 February 2011, it purchased for cancellation 726,330 ordinary shares of AstraZeneca PLC at a price of 3033 pence per share.

Some of these shares were purchased under the terms of the previously announced irrevocable, non-discretionary share repurchase programme for the period 21 February 2011 to 28 April 2011.

Upon the cancellation of these shares, the number of shares in issue will be 1,394,120,603.

A C N Kemp

Company Secretary

22 February 2011