Transaction in Own Shares

REPURCHASE OF SHARES IN ASTRAZENECA PLC

AstraZeneca PLC announced that on 22 September 2010, it purchased for cancellation 784,343 ordinary shares of AstraZeneca PLC at a price of 3346 pence per share.

Some of these shares were purchased under the terms of the previously announced irrevocable, non-discretionary share repurchase programme for the period 9 August 2010 to 10 December 2010.

Upon the cancellation of these shares, the number of shares in issue will be 1,428,896,223.

A C N Kemp

Company Secretary

23 September 2010