Transaction in Own Shares

SHIRE PLC - Transaction in Own Shares

PR Newswire

London, May 6

Transaction in Own Shares

May 7, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"), announcesthat in accordance with the authority granted by shareholders at the Company'sAnnual General Meeting on April 30, 2013 it purchased 220,000 of its ordinaryshares of 5 pence each ("Ordinary Shares") on May 3, 2013. The highest andlowest price paid for the directly acquired Ordinary Shares was 1884.00 penceper share and 1855.00 pence per share respectively.

The purchased shares will be held as treasury shares. Following the abovepurchase, the Company holds 8,204,097 Ordinary Shares as treasury shares andhas 554,622,325 Ordinary Shares in issue (excluding treasury shares).

The purchases were made by an independent third party which makes its tradingdecisions independently of, and uninfluenced by the Company. The independenceof the third party enables the Company to continue to purchase Ordinary Sharesduring close periods and other prohibited periods, should they arise. The thirdparty has been appointed by the Company to make purchases to December 31, 2013.

For further information please contact:

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs.

We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,Internal Medicine and Regenerative Medicine and we are developing treatmentsfor symptomatic conditions treated by specialist physicians in other targetedtherapeutic areas.

www.shire.com