Transaction in Own Shares

Transaction in Own Shares October 18, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announcesthat, in accordance with the authority granted by shareholders at the Company'sAnnual General Meeting on April 30, 2013, it purchased 2,700 of its ordinaryshares of 5 pence each ("Ordinary Shares") on October 17, 2013. The highest andlowest price paid for the directly acquired Ordinary Shares was 2523.00 penceper share and 2515.00 pence per share respectively. The purchased shares will be held as treasury shares. Following the abovepurchase, the Company holds 9,801,837 Ordinary Shares as treasury shares andhas 553,130,170 Ordinary Shares in issue (excluding treasury shares). The purchases were made by an independent third party which makes its tradingdecisions independently of, and uninfluenced by, the Company. The independenceof the third party enables the Company to continue to purchase Ordinary Sharesduring close periods and other prohibited periods, should they arise. The thirdparty has been appointed by the Company to make purchases to December 31, 2013. For further information please contact: Investor Relations Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,Internal Medicine and Regenerative Medicine and we are developing treatmentsfor symptomatic conditions treated by specialist physicians in other targetedtherapeutic areas. Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX www.shire.com