Transaction in Own Shares

SHIRE PLC - Transaction in Own Shares

PR Newswire

London, February 14

Transaction in Own Shares

February 15, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"),announces that in accordance with the authority granted by shareholders at theCompany's Annual General Meeting on April 24, 2012 it purchased 177,900 of itsordinary shares of 5 pence each ("Ordinary Shares") on February 14, 2013through both direct purchases of Ordinary Shares and through the purchase ofOrdinary Shares underlying ADRs. The highest and lowest price paid for thedirectly acquired Ordinary Shares was 2139.00 pence per share and 2027.00 penceper share respectively and for those Ordinary Shares acquired through thepurchase of ADRs was 3140.00 cents per share and 3116.33 cents per sharerespectively.

The purchased shares will be held as treasury shares. Following the abovepurchase, the Company holds 4,954,174 Ordinary Shares as treasury shares andhas 557,607,704 Ordinary Shares in issue (excluding treasury shares).

The purchases were made by an independent third party which makes its tradingdecisions independently of, and uninfluenced by the Company. The independenceof the third party enables the Company to continue to purchase Ordinary Shares(including Ordinary Shares underlying ADRs) during close periods and otherprohibited periods, should they arise. The third party has been appointed bythe Company to make purchases to December 31, 2013.

For further information please contact:

Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients' needs, we develop and providehealthcare in the areas of:

as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value forpatients, physicians, policymakers, payors and our shareholders.

www.shire.com

www.shire.com