Transaction in Own Shares

Transaction in Own Shares September 18, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company")announces that, in accordance with the authority granted by shareholders at theCompany's Annual General Meeting on April 30, 2013, it purchased 6,174 of itsordinary shares of 5 pence each ("Ordinary Shares") on September 17, 2013through both direct purchases of Ordinary Shares, and through the purchase ofOrdinary Shares underlying ADRs. The highest and lowest price paid for thedirectly acquired Ordinary Shares was 2564.00 pence per share and 2528.00 penceper share respectively, and for those Ordinary Shares acquired though thepurchase of ADRs was 4066.67 cents per share and 4057.67 cents per sharerespectively. The purchased shares will be held as treasury shares. Following the abovepurchase, the Company holds 9,719,306 Ordinary Shares as treasury shares andhas 553,172,347 Ordinary Shares in issue (excluding treasury shares). The purchases were made by an independent third party which makes its tradingdecisions independently of, and uninfluenced by, the Company. The independenceof the third party enables the Company to continue to purchase Ordinary Shares(including Ordinary Shares underlying ADRs) during close periods and otherprohibited periods, should they arise. The third party has been appointed bythe Company to make purchases to December 31, 2013. For further information please contact: Investor Relations Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,Internal Medicine and Regenerative Medicine and we are developing treatmentsfor symptomatic conditions treated by specialist physicians in other targetedtherapeutic areas. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com