Transaction in Own Shares

SHIRE PLC - Transaction in Own Shares

PR Newswire

London, February 1

Transaction in Own Shares

February 1, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"),announces that in accordance with the authority granted by shareholders at theCompany's Annual General Meeting on April 24, 2012 it purchased 16,700 of itsordinary shares of 5 pence each ("Ordinary Shares") on January 31, 2013 throughboth direct purchases of Ordinary Shares and through the purchase of OrdinaryShares underlying ADRs. The highest and lowest price paid for the directlyacquired Ordinary Shares was 2120.00 pence per share and 2103.00 pence pershare respectively and for those Ordinary Shares acquired through the purchaseof ADRs was 3351.33 cents per share and 3340.00 cents per share respectively.

The purchased shares will be held as treasury shares. Following the abovepurchase, the Company holds 4,683,074 Ordinary Shares as treasury shares andhas 557,872,464 Ordinary Shares in issue (excluding treasury shares).

The purchases were made by an independent third party which makes its tradingdecisions independently of, and uninfluenced by the Company. The independenceof the third party enables the Company to continue to purchase Ordinary Shares(including Ordinary Shares underlying ADRs) during close periods and otherprohibited periods, should they arise. The third party has been appointed bythe Company to make purchases to December 31, 2013.

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Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients' needs, we develop and providehealthcare in the areas of:

as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value forpatients, physicians, policymakers, payors and our shareholders.

www.shire.com