Transaction in Own Shares

SHIRE PLC - Transaction in Own Shares

PR Newswire

London, March 25

Transaction in Own Shares

March 25, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"), announcesthat in accordance with the authority granted by shareholders at the Company'sAnnual General Meeting on April 24, 2012 it purchased 107,000 of its ordinaryshares of 5 pence each ("Ordinary Shares") on March 22, 2013 through bothdirect purchases of Ordinary Shares and through the purchase of Ordinary Sharesunderlying ADRs. The highest and lowest price paid for the directly acquiredOrdinary Shares was 2002.00 pence per share and 1970.00 pence per sharerespectively and for those Ordinary Shares acquired through the purchase ofADRs was 3025.67 cents per share and 3019.33 cents per share respectively.

The purchased shares will be held as treasury shares. Following the abovepurchase, the Company holds 5,762,988 Ordinary Shares as treasury shares andhas 557,042,053 Ordinary Shares in issue (excluding treasury shares).

The purchases were made by an independent third party which makes its tradingdecisions independently of, and uninfluenced by the Company. The independenceof the third party enables the Company to continue to purchase Ordinary Shares(including Ordinary Shares underlying ADRs) during close periods and otherprohibited periods, should they arise. The third party has been appointed bythe Company to make purchases to December 31, 2013.

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Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients' needs, we develop and providehealthcare in the areas of:

as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value forpatients, physicians, policymakers, payors and our shareholders.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

www.shire.com