Transaction in Own Shares

REPURCHASE OF SHARES IN ASTRAZENECA PLC

AstraZeneca PLC announced that on 24 February 2011, it purchased for cancellation 980,102 ordinary shares of AstraZeneca PLC at a price of 2942 pence per share.

Some of these shares were purchased under the terms of the previously announced irrevocable, non-discretionary share repurchase programme for the period 21 February 2011 to 28 April 2011.

Upon the cancellation of these shares, the number of shares in issue will be 1,392,398,798.

A C N Kemp

Company Secretary

25 February 2011