Transaction in Own Shares

Transaction in Own Shares October 25, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announcesthat, in accordance with the authority granted by shareholders at the Company'sAnnual General Meeting on April 30, 2013, it purchased 1,250 of its ordinaryshares of 5 pence each ("Ordinary Shares") on October 24, 2013. The highest andlowest price paid for the directly acquired Ordinary Shares was 2529.00 penceper share and 2510.00 pence per share respectively. The purchased shares will be held as treasury shares. Following the abovepurchase, the Company holds 9,809,085 Ordinary Shares as treasury shares andhas 553,136,082 Ordinary Shares in issue (excluding treasury shares). The purchases were made by an independent third party which makes its tradingdecisions independently of, and uninfluenced by, the Company. The independenceof the third party enables the Company to continue to purchase Ordinary Shares(including Ordinary Shares underlying ADRs) during close periods and otherprohibited periods, should they arise. The third party has been appointed bythe Company to make purchases to December 31, 2013. For further information please contact: Investor Relations Eric Rojas erojas@shire.com +1 781 482 0999 Sarah Elton-Farr seltonfarr@shire.com +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,Internal Medicine and Regenerative Medicine and we are developing treatmentsfor symptomatic conditions treated by specialist physicians in other targetedtherapeutic areas. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com