Transaction in Own Shares

SHIRE PLC - Transaction in Own Shares

PR Newswire

London, January 9

Transaction in Own Shares

January 10, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"),announces that in accordance with the authority granted by shareholders at theCompany's Annual General Meeting on April 24, 2012 it purchased 154,251 of itsordinary shares of 5 pence each ("Ordinary Shares") on January 9, 2013. Thehighest and lowest price paid for the directly acquired Ordinary Shares was2008.00 pence per share and 1978.00 pence per share respectively.

The purchased shares will be held as treasury shares. Following the abovepurchase, the Company holds 4,261,111 Ordinary Shares as treasury shares andhas 558,289,504 Ordinary Shares in issue (excluding treasury shares).

The purchases were made by an independent third party which makes its tradingdecisions independently of, and uninfluenced by the Company. The independenceof the third party enables the Company to continue to purchase Ordinary Sharesduring close periods and other prohibited periods, should they arise. The thirdparty has been appointed by the Company to make purchases to December 31, 2013.

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Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients' needs, we develop and providehealthcare in the areas of:

as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value forpatients, physicians, policymakers, payors and our shareholders.

www.shire.com