Transaction in Own Shares

SHIRE PLC - Transaction in Own Shares

PR Newswire

London, December 20

Transaction in Own Shares

December 21, 2012 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"),announces that in accordance with the authority granted by shareholders at theCompany's Annual General Meeting on April 24, 2012 it purchased 61,000 of itsordinary shares of 5 pence each on December 20, 2012. The highest and lowestprice paid for these shares was 1937.00 pence per share and 1923.00 pence pershare respectively.

The purchased shares will be held as treasury shares. Following the abovepurchase, the Company holds 3,547,571 ordinary shares as treasury shares andhas 558,997,941 ordinary shares in issue (excluding treasury shares).

The purchases were made by an independent third party which makes its tradingdecisions independently of, and uninfluenced by the Company. The independenceof the third party enables the Company to continue to purchase ordinary shares(including ordinary shares underlying ADRs) during close periods and otherprohibited periods, should they arise. The third party has been appointed bythe Company to make purchases to December 31, 2013.

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Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients' needs, we develop and providehealthcare in the areas of:

as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value forpatients, physicians, policymakers, payors and our shareholders.

www.shire.com