TR-1: Notification of Major Interest in Shares

27th Jul 2012 12:12

For filings with issuer exclude the annex

TR-1:NOTIFICATION OF MAJOR INTEREST IN SHARES

1. Identity of the issuer or the underly Silence Therapeutics plc ing issuer of existing shares to which

voting rights are attached: ii

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights X

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which

voting rights are attached An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments An event changing the breakdown of voting rights Other (please specify): 3. Full name of person(s) subject t Hedger Management SA o the notification obligation : iii 4. Full name of shareholder(s) (if different from 3.):iv 5. Date of the transaction and date 27 July 2012on which the threshold is crossed or reached: v 6. Date on which issuer notified: 27 July 2012 7. Threshold(s) that is/are crossed Below 8%, Below 3% or reached: vi, vii 8. Notified details: A: Voting rights attached to shares viii, ix

Class/type of Situation previous to Resulting situation after the triggering t shares the triggering transa ransaction

cti on if possible

using the Number of Number of Number Number of voting % of voting rightISIN CODE Shares Voting R of share rights s x ights s Direct xi xii Direct Indirect Direct Indirect

GB0008433350 50,000,000 50,000,000 B: Qualifying Financial Instruments Resulting situation after the triggering transaction Type of financia Expiration Exercise/ Number of voting % of voting l instrument date xiii rights that may b rights Conversion e acquired if the Period xiv instrument is exe rcised/ converte d. N/A

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments

xv, xvi Resulting situation after the triggering transaction Type of finan Exercise Expiration Exercise/ Number of voting % of voting rigcia l inst price date xvii Conversion rights inst hts xix, rument period rument refers to xviii xx N/A Nominal Delta Total (A+B+C) Number of voting rights Percentage of voting rights

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable: xxi

Proxy Voting: 10. Name of the proxy holder: 11. Number of voting rights proxy holder will cease to hold: 12. Date on which proxy holder will cease to ho ld voting rights: 13. Additional informatio n: 14. Contact name: Charles John Bennett

15. Contact telephone number: +41 22 809 9500

XLON

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Related Shares:

SLN.L