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TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARES

20th May 2011 09:26

For filings with the FSA include the annex For filings with issuer exclude the annex TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi 1. Identity of the issuer or the underlying issuer SILENCE THERAPEUTICS PLCof existing shares to which voting rights are attached:ii 2 Reason for the notification (please tick the appropriate box or boxes): An acquisition or disposal of voting rights An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached An acquisition or disposal of instruments with similar economic effect to Xqualifying financial instruments An event changing the breakdown of voting rights Other (please specify): 3. Full name of person(s) subject to the ROBERT KEITHnotification obligation:iii 4. Full name of shareholder(s) Rock (Nominees) Limited (if different from 3.):iv 5. Date of the transaction and date on which the threshold is crossed or 17.05.11reached: v 6. Date on which issuer notified: 19.05.11 7. Threshold(s) that is/are crossed or 11%reached: vi, vii 8. Notified details: A: Voting rights attached to shares viii, ix Class/type of Situation previous Resulting situation after the triggering transaction shares to the triggering transaction if possible Number Number Number Number of voting % of voting rightsusing of of of shares rights x the ISIN CODE Shares Voting Rights Direct Direct xi Indirect Direct Indirect xii 51,000,000 8.8% 51,000,000 51,000,000 8.8% GB0008433350 B: Qualifying Financial Instruments Resulting situation after the triggering transaction Type of financial Expiration Exercise/ Number of voting % of voting instrument date xiii Conversion Period xiv rights that may be rights acquired if the instrument is exercised/ converted. C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi Resulting situation after the triggering transaction Type of Exercise Expiration Exercise/ Number of voting rights % of voting financial price date xvii Conversion instrument refers to rights xix, xx instrument period xviii Nominal Delta Spreadbet n/a n/a n/a 13,236,216 2.3% 2.3% Total (A+B+C) Number of voting rights Percentage of voting rights 64,236,216 11.1%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable: xxi

Proxy Voting: 10. Name of the proxy holder: 11. Number of voting rights proxy holder will cease to hold: 12. Date on which proxy holder will cease to hold voting rights: 13. Additional information: 14. Contact name: ROBERT KEITH 15. Contact telephone number: 0207 491 0581

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