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TR-1: Notification Of Major Interest In Shares

19th May 2011 13:52

For filings with the FSA include the annex For filings with issuer exclude the annex TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi 1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are Silence Therapeutics Plcattached:ii 2 Reason for the notification (please tick the appropriate box or boxes): An acquisition or disposal of voting rights Yes

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments An event changing the breakdown of voting rights Other (please specify):

3. Full name of person(s) subject to the CreditAgricole Cheuvreux International Ltd notification obligation:iii

4. Full name of shareholder(s) (if different from 3.):iv 5. Date of the transaction and date on which the threshold is crossed or 17/05/11reached: v 6. Date on which issuer notified: 19/05/11 7. Threshold(s) that is/are crossed or Below 5%reached: vi, vii 8. Notified details: A: Voting rights attached to shares viii, ix

Class/type Situation previous Resulting situation after the triggering transaction of

to the triggering shares transaction Number Number Number Number of voting % of voting rights xif possible of of of shares rights using Shares Voting the ISIN Rights Direct Direct xi Indirect Direct IndirectCODE xii GB0008433350

34,162,807 34,162,807 Less than 5% Less than 5% Less than 5% B: Qualifying Financial Instruments Resulting situation after the triggering transaction Type of Expiration Exercise/ Number of voting % of voting financial date xiii Conversion Period xiv rights that may be rights instrument acquired if the instrument is exercised/ converted. C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi Resulting situation after the triggering transaction Type of Exercise Expiration Exercise/ Number of voting rights % of voting financial price date xvii Conversion instrument refers to rights xix, xx instrument period xviii Nominal Delta Total (A+B+C) Number of voting rights Percentage of voting rights Less than 5% Less than 5%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable: xxi

SAS Rue La Bo©tie Cr©dit Agricole SA Calyon SA Cr©dit Agricole Cheuvreux SA Cr©dit Agricole Cheuvreux International Limited Less than 5% Proxy Voting: 10. Name of the proxy holder: 11. Number of voting rights proxy holder will cease to hold: 12. Date on which proxy holder will cease to hold voting rights: 13. Additional information: 14. Contact name: Olanike Bola-Lateef 15. Contact telephone number: 0207 214 6519

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