TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARES

17th May 2011 17:38

For filings with the FSA include the annex For filings with issuer exclude the annex TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi 1. Identity of the issuer or the underlying issuer Silence Therapeutics of existing shares to which voting rights are Plc attached:ii (GB0008433350) 2 Reason for the notification (please tick the appropriate box or boxes): An acquisition or disposal of voting rights X An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments An event changing the breakdown of voting rights Other (please specify): 3. Full name of person(s) subject to the HEDGER MANAGEMENT SA notification obligation:iii 4. Full name of shareholder(s) (if different from 3.):iv 5. Date of the transaction and date on which the threshold is crossed or 17th May 2011 reached: v 6. Date on which issuer notified: 17th May 2011 7. Threshold(s) that is/are crossed or 8% reached: vi, vii 8. Notified details: A: Voting rights attached to shares viii, ix

Class/type Situation previous Resulting situation after the triggering of

to the triggering transaction shares transaction Number Number Number Number of voting % of voting if possible of of of shares rights rights x using Shares Voting the ISIN Rights Direct Direct xi Indirect Direct Indirect CODE xii GB0008433350 nil 50,000,000 50,000,000 8.67% B: Qualifying Financial Instruments Resulting situation after the triggering transaction Type of Expiration Exercise/ Number of voting % of voting financial date xiii Conversion Period xiv rights that may be rights instrument acquired if the instrument is exercised/ converted. N/A C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi Resulting situation after the triggering transaction Type of Exercise price Expiration Exercise/ Number of voting % of voting financial date xvii Conversion rights instrument rights xix, xxinstrument period refers to xviii Nominal Delta N/A Total (A+B+C) Number of voting rights Percentage of voting rights 50,000,000 8.67%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable: xxi

Proxy Voting: 10. Name of the proxy holder: 11. Number of voting rights proxy holder will cease to hold: 12. Date on which proxy holder will cease to hold voting rights: 13. Additional information: 14. Contact name: Richard Beech 15. Contact telephone number: 0161 828 0233

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Related Shares:

SLN.L