Total Voting Rights

Total Voting Rights May 1, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"), in accordancewith the Financial Conduct Authority's (the "FCA") Disclosure and TransparencyRule 5.6.1R, notifies the market of the following: At close of business on April 30, 2014, the Company's issued ordinary sharecapital comprised 589,014,068 ordinary shares of 5 pence each with votingrights and a further 9,019,832 ordinary shares held in treasury. Therefore the total number of voting rights in the Company is 589,014,068. Thisis the figure which should be used by shareholders as the denominator for thecalculations by which they will determine if they are required to notify theirinterest in, or a change to their interest in, the Company under the FCA'sDisclosure and Transparency Rules. Tony GuthrieDeputy Company Secretary For further information please contact: Investor RelationsJeff Poulton [email protected] +1 781 482 0945Eric Rojas [email protected] +1 781 482 0999Sarah Elton-Farr [email protected] +44 1256 894157 Notes to editors Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal andInternal Medicine and we are developing treatments for symptomatic conditionstreated by specialist physicians in other targeted therapeutic areas. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com