Total Voting Rights

Total Voting Rights December 1, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"), inaccordance with the Financial Conduct Authority's (the "FCA") Disclosure andTransparency Rule 5.6.1R, notifies the market of the following: As at November 30, 2014, the Company's issued ordinary share capital comprised589,996,499 ordinary shares of 5 pence each with voting rights and a further9,019,832 ordinary shares held in treasury. Therefore the total number of voting rights in the Company is 589,996,499. Thisis the figure which should be used by shareholders as the denominator for thecalculations by which they will determine if they are required to notify theirinterest in, or a change to their interest in, the Company under the FCA'sDisclosure and Transparency Rules. Tony GuthrieDeputy Company Secretary For further information please contact: Investor Relations Jeff Poulton [email protected] +1 781 482 0945 Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Neuroscience, Rare Diseases,Gastrointestinal, and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmics. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com