Total Voting Rights

Press Release www.shire.com Total Voting Rights May 1, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"), in accordancewith the Financial Conduct Authority's (the "FCA") Disclosure and TransparencyRule 5.6.1R, notifies the market of the following: As at April 30, 2015, the Company's issued ordinary share capital comprised591,651,753 ordinary shares of 5 pence each with voting rights and a further8,653,004 ordinary shares held in treasury. Therefore the total number of voting rights in the Company is 591,651,753. Thisis the figure which should be used by shareholders as the denominator for thecalculations by which they will determine if they are required to notify theirinterest in, or a change to their interest in, the Company under the FCA'sDisclosure and Transparency Rules. Tony GuthrieDeputy Company Secretary For further information please contact: Investor RelationsSarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Rare Diseases, Neuroscience,Gastrointestinal and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmics. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX