Total Voting Rights

Silence Therapeutics plc ("Silence" or the "Company")

TVR

In accordance with the Financial Services Authority's Disclosure and Transparency Rules, the Company hereby announces that it has 1,871,552,737 ordinary shares of 0.1p each ("Ordinary Shares") in issue, with each Ordinary Share carrying the right to one vote. The Company does not hold any Ordinary Shares in Treasury.

The above figure of 1,871,552,737 Ordinary Shares may be used by shareholders in the Company as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the share capital of the Company under the Financial Services Authority's Disclosure and Transparency Rules.