Total Voting Rights

SHIRE PLC - Total Voting Rights

PR Newswire

London, July 1

Total Voting Rights

July 1, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”), in accordance with the Financial Conduct Authority's (the “FCA”) Disclosure and Transparency Rule 5.6.1R, notifies the market of the following:

As at June 30, 2015, the Company’s issued ordinary share capital comprised 591,887,510 ordinary shares of 5 pence each with voting rights and a further 8,570,078 ordinary shares held in treasury.

Therefore the total number of voting rights in the Company is 591,887,510. This is the figure which should be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the Company under the FCA's Disclosure and Transparency Rules.

Tony GuthrieDeputy Company Secretary

For further information please contact:

NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty medicines to meet significant unmet patient needs.

We focus on providing treatments in Rare Diseases, Neuroscience, Gastrointestinal and Internal Medicine and we are developing treatments for symptomatic conditions treated by specialist physicians in other targeted therapeutic areas, such as Ophthalmics.

www.shire.com