Termination of Share Buyback program

Termination of Share Buyback program 11 November, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company")announces that the Company's share buyback program of up to $500 millionannounced on October 25, 2012, has today been terminated. Since the initiation of the share buyback $300 million has been returned toshareholders, through the purchase of 9,823,536 shares at an average price of £19.46. For further information please contact: Investor Relations Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,Internal Medicine and Regenerative Medicine and we are developing treatmentsfor symptomatic conditions treated by specialist physicians in other targetedtherapeutic areas. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com