Shire extends tender offer for ViroPharma

Shire extends tender offer for ViroPharma Dublin, Ireland - January 10, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG)announces that it has extended the expiration of its previously announcedtender offer by a wholly owned subsidiary of Shire for all of the outstandingcommon shares of ViroPharma Incorporated (NASDAQ: VPHM) until midnight, NewYork City time, on Thursday, January 23, 2014 (one minute after 11:59 p.m., NewYork City time, on January 23, 2014). The tender offer had previously beenscheduled to expire at midnight, New York City time, on Thursday, January 9,2014 (one minute after 11:59 p.m., New York City time, on January 9, 2014). Allof the other terms and conditions of the tender offer remain unchanged. As of midnight on January 9, 2014, approximately 51,571,041 common shares ofViroPharma (excluding 2,120,493 common shares of ViroPharma guaranteed to bedelivered within the next three NASDAQ trading days) had been validly tenderedand not withdrawn pursuant to the tender offer, representing approximately 78percent of the outstanding common shares of ViroPharma. For further information please contact: Investor Relations Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 Media Jessica Mann [email protected] +44 1256 894 280 Gwen Fisher [email protected] +1 484 595 9836 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,Internal Medicine and Regenerative Medicine and we are developing treatmentsfor symptomatic conditions treated by specialist physicians in other targetedtherapeutic areas. www.shire.com ADDITIONAL INFORMATION AND WHERE TO FIND IT This announcement is for informational purposes only and does not constitute anoffer to purchase or a solicitation of an offer to sell ViroPharma commonstock. The offer to buy ViroPharma common stock is being made pursuant to atender offer statement (including the offer to purchase, letter of transmittaland other related tender offer materials) filed by Shire PharmaceuticalHoldings Ireland Limited (SPHIL) and a subsidiary of SPHIL with the U.S.Securities and Exchange Commission (SEC) on November 25, 2013. In addition, onNovember 25, 2013, ViroPharma filed with the SEC a solicitation/recommendationstatement on Schedule 14D-9 with respect to the tender offer. Investors andsecurity holders are urged to read both the tender offer statement and thesolicitation/recommendation statement as they contain important information,including the terms and conditions of the tender offer, that should be readcarefully before any decision is made with respect to the tender offer. Investors and security holders may obtain a free copy of these materials andother documents filed by SPHIL and ViroPharma with the SEC at the websitemaintained by the SEC at http://www.sec.gov/. The tender offer statement andrelated materials, and the solicitation/recommendation statement, may also beobtained for free by contacting the information agent for the offer, MacKenziePartners, Inc., at (212) 929-5500 or toll-free at (800) 322-2885. Copies of these materials and any documentation relating to the tender offerare not being, and must not be, directly or indirectly, mailed or otherwiseforwarded, distributed or sent in, into or from any jurisdiction where to do sowould be unlawful. FORWARD - LOOKING STATEMENTS Statements included in this announcement that are not historical facts areforward-looking statements. Forward-looking statements involve a number ofrisks and uncertainties and are subject to change at any time. In the eventsuch risks or uncertainties materialize, Shire's results could be materiallyadversely affected. The risks and uncertainties include, but are not limitedto, that: * Shire's proposed acquisition of ViroPharma may not be consummated due to the occurrence of an event, change or other circumstances that gives rise to the termination of the merger agreement; * a governmental or regulatory approval required for the proposed acquisition of ViroPharma may not obtained, or may be obtained subject to conditions that are not anticipated, or another condition to the closing of the proposed acquisition may not be satisfied; * ViroPharma may be unable to retain and hire key personnel and/or maintain its relationships with customers, suppliers and other business partners pending the consummation of the proposed acquisition by Shire, or ViroPharma's business may be disrupted by the proposed acquisition, including increased costs and diversion of management time and resources; and * difficulties in integrating ViroPharma into Shire may lead to the combined company not being able to realize the expected operating efficiencies, cost savings, revenue enhancements, synergies or other benefits at the time anticipated or at all; and other risks and uncertainties detailed from time to time in Shire's orViroPharma's filings with the U.S. Securities and Exchange Commission,including their respective most recent Annual Reports on Form 10-K. Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com