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Shire Executive Annual Incentive Plan

2nd Apr 2007 17:22

2 April 2007

Shire plc ("Shire")

Shire plc (the "Company") - Shire Executive Annual Incentive Plan

The Shire Executive Annual Incentive Plan ("the Plan") provides for annual awards to participants partly in cash, which is payable immediately, and partly in shares and ADSs , which will not be released for a period of three years.

On 30 March 2007, the trustee of the Shire plc Employee Benefit Trust (the "Trust") acquired 33,584 Ordinary Shares in Shire plc at a price of ‚£10.53 per Ordinary Share and 24,518 American Depository Shares ("ADS"s) in Shire plc at a price of USD62.1575 per ADS for use in relation to the Plan.

The Company's Executive Directors and persons discharging managerial responsibility, are potential beneficiaries of the Trust and are therefore deemed to have an interest in the Shares and ADSs held by the Trust.

For further information please contact:

Investor Relations Clĩa Rosenfeld (Rest of the World) +44 1256 894 160 Eric Rojas (North America) +1 484 595 8252 Notes to editorsSHIRE PLC

Shire's strategic goal is to become the leading specialty pharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit and hyperactivity disorder (ADHD), human genetic therapies (HGT), gastrointestinal (GI) and renal diseases. The structure is sufficiently flexible to allow Shire to target new therapeutic areas to the extent opportunities arise through acquisitions. Shire believes that a carefully selected portfolio of products with a strategically aligned and relatively small-scale sales force will deliver strong results.

Shire's focused strategy is to develop and market products for specialty physicians. Shire's in-licensing, merger and acquisition efforts are focused on products in niche markets with strong intellectual property protection either in the US or Europe.

For further information on Shire, please visit the Company's website: www.shire.com.

Hampshire International Business Park Chineham Basingstoke Hampshire RG24 8EP United Kingdom Tel +44 (0)1256 894000 Fax +44 (0)1256 894708 www.shire.com Press Release

Registered in England 5492592 Registered Office as above

SHIRE PLC

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