Share Repurchase Programme

ASTRAZENECA PLC IRREVOCABLE, NON-DISCRETIONARY SHARE REPURCHASE PROGRAMME

AstraZeneca PLC today announced that, further to the announcement made on 6 May 2011 in relation to an irrevocable, non-discretionary programme with Barclays Bank PLC to purchase ordinary shares on AstraZeneca's behalf during the period which commenced on 9 May 2011 and was due to end on 26 August 2011, the programme will be extended by one additional trading day and will end on 30 August 2011. Any purchases will be made within certain pre-set parameters and in accordance with both AstraZeneca PLC's general authority to repurchase shares and the Listing Rules.

A C N Kemp

Company Secretary

26 August 2011