Share Repurchase Programme

ASTRAZENECA PLC IRREVOCABLE, NON-DISCRETIONARY SHARE REPURCHASE PROGRAMME

AstraZeneca PLC (the "Company") today announced that, further to the announcement made on 15 December 2011 in relation to an irrevocable, non-discretionary programme with Barclays Bank PLC to purchase ordinary shares on AstraZeneca's behalf during the period which commenced on 20 December 2011 and was due to end on 2 February 2012, the programme will be extended, in accordance with its terms, by four additional trading days and will end on 8 February 2012.

Any purchases will be made within certain pre-set parameters and in accordance with both the Company's general authority to repurchase shares and the Listing Rules. The Company intends to cancel any shares so acquired.

A C N Kemp

Company Secretary

2 February 2012