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Rule 8.1- Tissue Science Lab.

13th Mar 2008 14:05

Covidien UK Holding Ltd13 March 2008 The Rule 8.1 - Tissue Science Laboratories plc announcement released today at07.02 under RNS number 9948P has been amended. Of the purchases identified in 2(a) and 3(a) 1,116,591 shares related to a Letter of Intent granted by InvescoPerpetual to Covidien UK Holding Ltd as announced at 07.04 on 12 March 2008under RNS number 8978P. Therefore these shares are no longer included in thetotal of irrevocables and letters of intent that Covidien UK Holding Ltd hasreceived. The fully amended text is shown below FORM 8.1 DEALINGS BY OFFERORS, OFFEREE COMPANIES OR THEIR ASSOCIATES FOR THEMSELVES OR FOR DISCRETIONARY CLIENTS (Rules 8.1(a) and (b)(i) of the Takeover Code) 1. KEY INFORMATION Name of person dealing (Note 1) Covidien UK Holding Ltd (an indirect wholly-owned subsidiary of Covidien Ltd) Company dealt in Tissue Science Laboratories plc Class of relevant security to which the Ordinary shares of 10 pence eachdealings being disclosed relate (Note 2) Date of dealing 12 March 2008 2. INTERESTS, SHORT POSITIONS AND RIGHTS TO SUBSCRIBE (a) Interests and short positions (following dealing) in the class ofrelevant security dealt in (Note 3) Long Short Number Number (%) (%) (1) Relevant securities 3,977,518 * (11.4%) (2) Derivatives (other than options) (3) Options and agreements to purchase/sell Total 3,977,518 * (11.4%) * 1,116,591 of the shares related to a Letter of Intent granted by InvescoPerpetual to Covidien UK Holding Ltd as announced at 07.04 on 12 March 2008under RNS number 8978P. Therefore these shares are no longer included in thetotal of irrevocables and letters of intent that Covidien UK Holding Ltd hasreceived. (b) Interests and short positions in relevant securities of the company,other than the class dealt in (Note 3) Class of relevant security: Long Short Number Number (%) (%) (1) Relevant securities (2) Derivatives (other than options) (3) Options and agreements to purchase/sell Total (c) Rights to subscribe (Note 3) Class of relevant security: Details 3. DEALINGS (Note 4) (a) Purchases and sales Purchase/sale Number of securities Price per unit (Note 5) 100,000 100 pence Purchase 3,877,518* 101.5 pence * 1,116,591 of the shares related to a Letter of Intent granted by InvescoPerpetual to Covidien UK Holding Ltd as announced at 07.04 on 12 March 2008under RNS number 8978P. Therefore these shares are no longer included in thetotal of irrevocables and letters of intent that Covidien UK Holding Ltd hasreceived. (b) Derivatives transactions (other than options) Product name, Long/short (Note 6) Number of securities (Note 7) Price per unit (Note 5)e.g. CFD (c) Options transactions in respect of existing securities (i) Writing, selling, purchasing or varying Product name, Writing, selling, Number of securities Exercise Type, e.g. Expiry Option money purchasing, to which the option price American, date paid/received pere.g. call option varying etc. relates (Note 7) European etc. unit (Note 5) (ii) Exercising Product name, e.g. call option Number of securities Exercise price per unit (Note 5) (d) Other dealings (including new securities) (Note 4) Nature of transaction (Note 8) Details Price per unit (if applicable) (Note 5) 4. OTHER INFORMATION Agreements, arrangements or understandings relating to options or derivatives Full details of any agreement, arrangement or understanding between the person disclosing and any other person relatingto the voting rights of any relevant securities under any option referred to on this form or relating to the votingrights or future acquisition or disposal of any relevant securities to which any derivative referred to on this form isreferenced. If none, this should be stated. Is a Supplemental Form 8 attached? (Note 9) NO Date of disclosure 13 March 2008 Contact name Mark Culwick Telephone number 0121 600 5227 Name of offeree/offeror with which associated n.a.Specify category and nature of associate status (Note 10) n.a. This information is provided by RNS The company news service from the London Stock Exchange

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