Results of the 2015 Annual General Meeting

Results of the 2015 Annual General Meeting April 28, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announcesthat at its Annual General Meeting held at The Merrion Hotel, Upper MerrionStreet, Dublin 2, Ireland at 2.45pm today, all resolutions contained in theNotice of Meeting were decided by poll vote. The results of the poll are asfollows: Resolutions For % Against % Votes cast Withheld (including as a % of discretionary relevant votes) shares in issue Ordinary Resolutions 1. To receive the 438,413,528 99.13 3,865,083 0.87 74.76 1,417,850Company's Annual Reportand Accounts for the yearended December 31, 2014. 2. To approve the 429,855,512 97.20 12,372,754 2.80 74.75 1,468,195Directors' RemunerationReport. 3. To approve the 414,168,513 93.99 26,500,604 6.01 74.49 3,027,344Directors' RemunerationPolicy. 4. To elect Dominic 425,224,988 96.22 16,683,913 3.78 74.70 1,787,560Blakemore as a Director. 5. To re-elect William 440,687,897 99.64 1,573,615 0.36 74.75 1,434,949Burns as a Director. 6. To re-elect Dr. Steven 438,960,079 99.25 3,300,979 0.75 74.75 1,435,403Gillis as a Director. 7. To re-elect Dr. David 442,090,768 99.96 170,504 0.04 74.75 1,435,189Ginsburg as a Director. 8. To re-elect David 433,823,989 98.25 7,732,861 1.75 74.64 2,139,611Kappler as a Director. 9. To re-elect Susan 427,582,010 96.68 14,681,728 3.32 74.76 1,432,723Kilsby as a Director. 10. To re-elect Anne 429,569,604 97.15 12,580,758 2.85 74.74 1,546,099Minto as a Director. 11. To re-elect Dr. 442,091,049 99.96 174,121 0.04 74.76 1,431,291Flemming Ornskov as aDirector. 12 .To re-appoint 409,645,636 92.82 31,682,655 7.18 74.60 2,368,170Deloitte LLP as theCompany's Auditor. 13. To authorize the 417,660,298 94.45 24,549,709 5.55 74.75 1,486,454Audit, Compliance & RiskCommittee to determinethe remuneration of theAuditor. 14. To approve the Shire 395,422,460 90.35 42,216,836 9.65 73.97 6,057,165Long Term Incentive Plan2015. 15. To approve the Shire 437,887,308 99.22 3,427,952 0.78 74.59 2,381,201Global Employee StockPurchase Plan. 16. To authorize the 415,267,543 94.42 24,518,586 5.58 74.34 3,910,332allotment of shares. Special Resolutions 17. To authorize the 424,987,901 96.89 13,648,641 3.11 74.14 5,059,919disapplication ofpre-emption rights. 18. To authorize 441,910,866 99.93 303,040 0.07 74.75 1,482,555purchases of own shares. 19. To approve the notice 391,913,232 88.61 50,365,471 11.39 74.76 1,417,758period for generalmeetings. As at the record date, April 26, 2015, there were 591,616,476 ordinary sharesin issue (excluding shares held in treasury). Shareholders are entitled to onevote per share. A vote "withheld" is not a vote in law and is not counted inthe calculation of the proportion of votes validly cast. In accordance with Listing Rule 9.6.2R copies of the relevant resolutionspassed at the meeting have been submitted to the National Storage Mechanism andwill be available for viewing shortly at: www.morningstar.co.uk/uk/nsm. Tony GuthrieDeputy Company Secretary For further information please contact: Investor Relations Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Rare Diseases, Neuroscience,Gastrointestinal and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmics.

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